THG1L

Description		tRNA-histidine guanylyltransferase 1 like
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GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Outer Membrane Cytosol Membrane Transferase Complex
	Molecular Function	TRNA Binding Nucleotide Binding Magnesium Ion Binding Guanyl-nucleotide Exchange Factor Activity Protein Binding ATP Binding GTP Binding TRNA Guanylyltransferase Activity Transferase Activity Nucleotidyltransferase Activity Identical Protein Binding Metal Ion Binding
	Biological Process	TRNA Modification Response To Oxidative Stress TRNA Processing Mitochondrial Fusion Protein Homotetramerization TRNA 5'-end Processing Stress-induced Mitochondrial Fusion
Pathways		tRNA modification in the nucleus and cytosol
Drugs
Diseases
GWAS		Red cell distribution width ( 32888494)
Novel Interacting Genes		8 novel interacting genes: ELMOD1 HAVCR2 LNX1 NTAQ1 PLEKHF2 SDCBP TERF1 UBC
Interacting Genes		8 interacting genes: ELMOD1 HAVCR2 LNX1 NTAQ1 PLEKHF2 SDCBP TERF1 UBC
Entrez ID		54974
HPRD ID		13726
Ensembl ID		ENSG00000113272
Uniprot IDs		B4E366 Q9H8R6 Q9NWX6
PDB IDs		3OTB 3OTC 3OTD 3OTE 7CV1
Enriched GO Terms of Interacting Partners?		Interleukin-5 Receptor Binding Interleukin-5 Receptor Complex Negative Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Establishment Of RNA Localization To Telomere Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Positive Regulation Of Shelterin Complex Assembly Protein-N-terminal Asparagine Amidohydrolase Activity Protein-N-terminal Glutamine Amidohydrolase Activity Negative Regulation Of Granulocyte Colony-stimulating Factor Production Negative Regulation Of Macrophage Colony-stimulating Factor Production Negative Regulation Of Interleukin-3 Production Negative Regulation Of Immunological Synapse Formation Regulation Of Tolerance Induction Dependent Upon Immune Response Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Natural Killer Cell Tolerance Induction Negative Regulation Of T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Positive Regulation Of Extracellular Exosome Assembly Syndecan Binding Negative Regulation Of Myeloid Dendritic Cell Activation Negative Regulation Of Interferon-alpha Production Negative Regulation Of Defense Response To Bacterium Toll-like Receptor 7 Signaling Pathway Regulation Of Extracellular Exosome Assembly Regulation Of Establishment Of Protein Localization To Telomere Shelterin Complex Regulation Of Macrophage Colony-stimulating Factor Production Regulation Of Establishment Of Protein Localization To Chromosome Telomerase Activity Ankyrin Repeat Binding Meiotic Telomere Clustering Chromosome Localization To Nuclear Envelope Involved In Homologous Chromosome Segregation Nuclear Telomere Cap Complex Telomere Localization Telomeric D-loop Disassembly Double-stranded Telomeric DNA Binding Substrate-dependent Cell Migration, Cell Extension G-rich Strand Telomeric DNA Binding Negative Regulation Of Natural Killer Cell Activation Telomeric Loop Disassembly Negative Regulation Of T-helper 1 Type Immune Response Toll-like Receptor 9 Signaling Pathway T-circle Formation Telomere Capping Positive Regulation Of Defense Response To Bacterium
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