SEMA4C

Description		semaphorin 4C
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GO Annotations	Cellular Component	Extracellular Space Plasma Membrane Postsynaptic Density Membrane Synaptic Vesicle Membrane Cytoplasmic Vesicle Synapse Postsynaptic Membrane Postsynaptic Density Membrane Glutamatergic Synapse
	Molecular Function	Protein Binding Semaphorin Receptor Binding Neuropilin Binding Chemorepellent Activity
	Biological Process	Neural Crest Cell Migration Neural Tube Closure Nervous System Development Axon Guidance Cell Migration In Hindbrain Cerebellum Development Cell Differentiation Positive Regulation Of Cell Migration Positive Regulation Of Stress-activated MAPK Cascade Muscle Cell Differentiation Negative Chemotaxis Semaphorin-plexin Signaling Pathway Regulation Of Postsynapse Assembly
Pathways
Drugs
Diseases
GWAS		Blood protein levels ( 30072576)
Novel Interacting Genes		20 novel interacting genes: CYSRT1 DLG1 DLG2 DLG3 DLG4 GIPC1 HSF2BP KRT16 KRT27 KRT31 KRT34 KRT40 KRTAP6-3 NBPF19 NCDN NOTCH2NLA PNMA1 RCHY1 TRIM54 USHBP1
Interacting Genes		20 interacting genes: CYSRT1 DLG1 DLG2 DLG3 DLG4 GIPC1 HSF2BP KRT16 KRT27 KRT31 KRT34 KRT40 KRTAP6-3 NBPF19 NCDN NOTCH2NLA PNMA1 RCHY1 TRIM54 USHBP1
Entrez ID		54910
HPRD ID		07257
Ensembl ID		ENSG00000168758
Uniprot IDs		Q9C0C4
PDB IDs		6N5Z
Enriched GO Terms of Interacting Partners?		Structural Constituent Of Skin Epidermis Intermediate Filament Intermediate Filament Organization Ionotropic Glutamate Receptor Binding Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament-based Process Receptor Localization To Synapse Receptor Clustering Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Establishment Or Maintenance Of Apical/basal Cell Polarity Protein Localization To Synapse Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Morphogenesis Of An Epithelium Structural Molecule Activity Neuromuscular Junction Protein Localization To Cell Junction Tissue Morphogenesis Kinase Binding Postsynaptic Density Membrane Supramolecular Fiber Organization Epidermis Development Chemical Synaptic Transmission Establishment Or Maintenance Of Cell Polarity Neuron Projection Trans-synaptic Signaling Synaptic Signaling GMP Kinase Activity Adherens Junction GDP Metabolic Process Epithelial Cell Differentiation Juxtaparanode Region Of Axon Cellular Response To Potassium Ion Anatomical Structure Morphogenesis Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Response To Potassium Ion Glutamatergic Synapse Protein Localization To Membrane Cytosol AMPA Glutamate Receptor Complex GMP Metabolic Process Cell-cell Signaling Protein Localization To Postsynaptic Membrane Signaling Protein Localization To Postsynapse Cytoskeleton Organization Cell Communication Establishment Of Skin Barrier Skin Epidermis Development Developmental Process
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