DCHS2

Description		dachsous cadherin-related 2
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Adherens Junction Membrane
	Molecular Function	Calcium Ion Binding
	Biological Process	Heart Morphogenesis Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Establishment Or Maintenance Of Cell Polarity Axonogenesis Cell Differentiation Epithelial Cell Differentiation Cell-cell Adhesion Mediated By Cadherin Tissue Morphogenesis Epithelium Development Nephron Development Condensed Mesenchymal Cell Proliferation Cell-cell Adhesion
Pathways
Drugs
Diseases
GWAS		Alzheimer's disease (age of onset) ( 22005931) Bilirubin levels ( 20639394) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Facial morphology traits (63 three-dimensional facial segments) ( 29459680) facial morphology traits (multivariate analysis) ( 27193062) Fibrinogen ( 21757653) Immune reponse to smallpox (secreted IL-1beta) ( 22610502) Macular thickness ( 30535121) middle facial morphology traits (quantitative measurement) ( 27193062) Nose morphology ( 29921221 33593615) Obesity-related traits ( 23251661) Schizophrenia, bipolar disorder or major depressive disorder ( 34099189) Schizophrenia, bipolar disorder or recurrent major depressive disorder x sex interaction ( 34099189) Thyrotoxic hypokalemic periodic paralysis and Graves disease ( 31050781) Type 2 diabetes (age of onset) ( 28060188)
Novel Interacting Genes		1 novel interacting genes: DYRK1A
Interacting Genes		1 interacting genes: DYRK1A
Entrez ID		54798
HPRD ID		10858
Ensembl ID		ENSG00000197410
Uniprot IDs		A0A0A0MRC0 Q6V1P8 Q6V1P9
PDB IDs
Enriched GO Terms of Interacting Partners?		Histone H3T45 Kinase Activity RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity Negative Regulation Of Heterochromatin Formation Regulation Of Neurofibrillary Tangle Assembly Neurofilament Splicing Factor Binding Regulation Of Heterochromatin Formation Negative Regulation Of Microtubule Polymerization Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Tau-protein Kinase Activity Negative Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Chromatin Organization Regulation Of Inclusion Body Assembly Protein Serine/threonine/tyrosine Kinase Activity Negative Regulation Of RNA Splicing Positive Regulation Of RNA Splicing Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Amyloid-beta Formation Negative Regulation Of Microtubule Polymerization Or Depolymerization Non-membrane Spanning Protein Tyrosine Kinase Activity Negative Regulation Of Signal Transduction By P53 Class Mediator Tau Protein Binding Regulation Of Amyloid Precursor Protein Catabolic Process Peptidyl-tyrosine Phosphorylation Regulation Of Microtubule Polymerization Tubulin Binding Cytoskeletal Protein Binding Double-strand Break Repair Via Nonhomologous End Joining Regulation Of Alternative MRNA Splicing, Via Spliceosome Regulation Of Amide Metabolic Process Actin Filament Regulation Of Microtubule Polymerization Or Depolymerization Negative Regulation Of MRNA Metabolic Process Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing Protein Autophosphorylation Double-strand Break Repair Via Homologous Recombination Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Protein-containing Complex Assembly Protein Tyrosine Kinase Activity Circadian Rhythm Recombinational Repair Negative Regulation Of Cytoskeleton Organization Negative Regulation Of Supramolecular Fiber Organization Regulation Of Microtubule Cytoskeleton Organization Regulation Of RNA Splicing Double-strand Break Repair DNA Recombination Rhythmic Process Regulation Of Microtubule-based Process
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