P4HTM

Description		prolyl 4-hydroxylase, transmembrane
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GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Procollagen-proline 4-dioxygenase Activity Iron Ion Binding Calcium Ion Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen 2-oxoglutarate-dependent Dioxygenase Activity L-ascorbic Acid Binding Metal Ion Binding Dioxygenase Activity Hypoxia-inducible Factor-proline Dioxygenase Activity
	Biological Process	Regulation Of Erythrocyte Differentiation
Pathways
Drugs		Ascorbic acid
Diseases
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908)
Novel Interacting Genes		10 novel interacting genes: DSCR9 F2RL1 GLP1R GPR37 LCOR LTB4R2 PDIA2 QRICH1 RHOU UBC
Interacting Genes		10 interacting genes: DSCR9 F2RL1 GLP1R GPR37 LCOR LTB4R2 PDIA2 QRICH1 RHOU UBC
Entrez ID		54681
HPRD ID		17842
Ensembl ID		ENSG00000178467
Uniprot IDs		Q9NXG6
PDB IDs		6TP5
Enriched GO Terms of Interacting Partners?		G Protein-coupled Peptide Receptor Activity G Protein-coupled Receptor Activity Proteinase-activated Receptor Activity Positive Regulation Of Glomerular Filtration Positive Regulation Of Neutrophil Mediated Killing Of Gram-negative Bacterium G Protein-coupled Receptor Signaling Pathway Regulation Of Renin Secretion Into Blood Stream Positive Regulation Of Eosinophil Degranulation Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Regulation Of Neutrophil Mediated Killing Of Gram-negative Bacterium Positive Regulation Of Renin Secretion Into Blood Stream Glucagon-like Peptide 1 Receptor Activity Glucagon Receptor Activity Neuropeptide Signaling Pathway Prosaposin Receptor Activity Leukotriene B4 Receptor Activity Leukotriene Receptor Activity
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