CRLS1

Description		cardiolipin synthase 1
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Membrane Mitochondrial Membrane
	Molecular Function	1-acylglycerol-3-phosphate O-acyltransferase Activity Transferase Activity Phosphotransferase Activity, For Other Substituted Phosphate Groups Cardiolipin Synthase (CMP-forming) 2-acylglycerol-3-phosphate O-acyltransferase Activity
	Biological Process	Lipid Metabolic Process Phospholipid Biosynthetic Process Cardiolipin Biosynthetic Process Phosphatidylglycerol Acyl-chain Remodeling Glycerophospholipid Biosynthetic Process
Pathways		Acyl chain remodelling of PG Synthesis of CL
Drugs
Diseases
GWAS		Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Triglyceride levels x loop diuretics use interaction ( 31806883)
Novel Interacting Genes		5 novel interacting genes: F2RL1 FBXO15 MCM6 MCM7 PINK1
Interacting Genes		5 interacting genes: F2RL1 FBXO15 MCM6 MCM7 PINK1
Entrez ID		54675
HPRD ID		12187
Ensembl ID		ENSG00000088766
Uniprot IDs		Q9UJA2
PDB IDs
Enriched GO Terms of Interacting Partners?		CMG Complex Double-strand Break Repair Via Break-induced Replication MCM Complex Regulation Of DNA-templated DNA Replication Initiation DNA Replication Initiation Negative Regulation Of JNK Cascade DNA Helicase Activity Proteinase-activated Receptor Activity Regulation Of JNK Cascade Positive Regulation Of Glomerular Filtration Positive Regulation Of Neutrophil Mediated Killing Of Gram-negative Bacterium Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Renin Secretion Into Blood Stream Positive Regulation Of Eosinophil Degranulation Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Regulation Of Neutrophil Mediated Killing Of Gram-negative Bacterium Protease Binding Positive Regulation Of Renin Secretion Into Blood Stream Helicase Activity Single-stranded DNA Binding Double-strand Break Repair Via Homologous Recombination Single-stranded 3'-5' DNA Helicase Activity Mitotic DNA Replication Recombinational Repair Regulation Of DNA Replication DNA Replication Positive Regulation Of Free Ubiquitin Chain Polymerization Positive Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Mitochondrion To Lysosome Vesicle-mediated Transport Positive Regulation Of Synaptic Transmission, Dopaminergic Cellular Response To Hydrogen Sulfide Positive Regulation Of Cristae Formation Negative Regulation Of Hydrogen Peroxide-induced Neuron Intrinsic Apoptotic Signaling Pathway Regulation Of Cristae Formation Negative Regulation Of MAPK Cascade Chromosome, Telomeric Region Positive Regulation Of Killing Of Cells Of Another Organism Response To Hydrogen Sulfide Mature Conventional Dendritic Cell Differentiation Thrombin-activated Receptor Activity C3HC4-type RING Finger Domain Binding Negative Regulation Of Mitochondrial Fission Maintenance Of Protein Location In Mitochondrion Regulation Of Synaptic Vesicle Transport Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Neutrophil Mediated Cytotoxicity Double-strand Break Repair Nuclear DNA Replication
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