RIN2

Description		Ras and Rab interactor 2
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Endocytic Vesicle
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity GTPase Regulator Activity Small GTPase Binding
	Biological Process	Endocytosis Signal Transduction Small GTPase-mediated Signal Transduction Positive Regulation Of Endothelial Cell Migration Vesicle-mediated Transport Positive Regulation Of Endothelial Cell-matrix Adhesion Via Fibronectin Positive Regulation Of Vasculogenesis
Pathways		RAB GEFs exchange GTP for GDP on RABs
Drugs
Diseases		Macrocephaly, alopecia, cutis laxa, and scoliosis; MACS syndrome
GWAS		Bipolar disorder and schizophrenia ( 20889312) Bone mineral density (total hip) ( 29883787) Femoral neck bone mineral density and trunk fat mass adjusted by trunk lean mass ( 32239398) HDL cholesterol ( 31170924) Metabolite levels ( 23823483) Obesity-related traits ( 23251661) Platelet distribution width ( 27863252 32888494) Response to valproic acid in genetic generalized epilepsy ( 32308125) Smoking status (ever vs never smokers) ( 30643258) Trunk fat mass adjusted for trunk lean mass ( 32239398) Verbal declarative memory ( 25648963) Weight ( 28552196)
Novel Interacting Genes		7 novel interacting genes: BIN1 CDKN2A EGFR ERBB2 RAB5A RAB5B RAB5C
Interacting Genes		7 interacting genes: BIN1 CDKN2A EGFR ERBB2 RAB5A RAB5B RAB5C
Entrez ID		54453
HPRD ID		15249
Ensembl ID		ENSG00000132669
Uniprot IDs		A1A4T0 Q8WYP3
PDB IDs
Enriched GO Terms of Interacting Partners?		Endocytic Vesicle Plasma Membrane To Endosome Transport Endosome Early Endosome Membrane Regulation Of Cellular Component Organization Negative Regulation Of Immature T Cell Proliferation In Thymus Negative Regulation Of Immature T Cell Proliferation G Protein Activity Cellular Localization GDP Binding ERBB2-EGFR Signaling Pathway Early Endosome Negative Regulation Of T Cell Differentiation In Thymus Melanosome Regulation Of Immature T Cell Proliferation In Thymus Endocytosis Regulation Of Vesicle-mediated Transport ERBB2 Signaling Pathway Regulation Of T Cell Differentiation In Thymus Import Into Cell Regulation Of Transport Endomembrane System Endosomal Transport Cellular Response To Epidermal Growth Factor Stimulus Endosome Membrane Regulation Of Endocytosis Negative Regulation Of T Cell Differentiation Nucleotide Binding Transmembrane Receptor Protein Tyrosine Kinase Activity Response To Epidermal Growth Factor Intracellular Protein Localization GTPase Activity Axon Terminus Negative Regulation Of Lymphocyte Differentiation Epidermal Growth Factor Receptor Signaling Pathway Basal Plasma Membrane GTP Binding Regulation Of Epithelial Cell Proliferation Positive Regulation Of Protein Modification Process Clathrin-coated Endocytic Vesicle Membrane Lipid Tube Negative Regulation Of Ventricular Cardiac Muscle Cell Action Potential Negative Regulation Of T Cell Proliferation Regulation Of Protein Phosphorylation Ligase Inhibitor Activity Regulation Of Cell Growth ERBB Signaling Pathway Multivesicular Body, Internal Vesicle Lumen Endosome Organization Regulation Of Phosphorylation
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