WNT4

Description		Wnt family member 4
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Endoplasmic Reticulum Lumen Golgi Lumen Plasma Membrane Cell Surface Endocytic Vesicle Membrane Extracellular Matrix Extracellular Exosome
	Molecular Function	Transcription Corepressor Activity Signaling Receptor Binding Frizzled Binding Cytokine Activity Receptor Ligand Activity
	Biological Process	Metanephros Development Branching Involved In Ureteric Bud Morphogenesis Kidney Development Mesonephros Development Epithelial To Mesenchymal Transition Embryonic Epithelial Tube Formation Liver Development Gamete Generation Sex Differentiation Fibroblast Growth Factor Receptor Signaling Pathway Male Gonad Development Female Gonad Development Cellular Response To Starvation Negative Regulation Of Gene Expression Negative Regulation Of Steroid Biosynthetic Process Wnt Signaling Pathway Regulation Of Cell-cell Adhesion Cell Differentiation Neuron Differentiation Female Sex Determination Adrenal Gland Development Negative Regulation Of Cell Migration Positive Regulation Of Bone Mineralization Positive Regulation Of Aldosterone Biosynthetic Process Positive Regulation Of Collagen Biosynthetic Process T Cell Differentiation In Thymus Immature T Cell Proliferation In Thymus Tube Morphogenesis Non-canonical Wnt Signaling Pathway Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Hormone Metabolic Process Positive Regulation Of MAPK Cascade Cell Fate Commitment Negative Regulation Of Cell Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Meiotic Nuclear Division Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Negative Regulation Of Ras Protein Signal Transduction Oocyte Development Branching Morphogenesis Of An Epithelial Tube Smooth Muscle Cell Differentiation Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Focal Adhesion Assembly Sertoli Cell Differentiation Canonical Wnt Signaling Pathway Somatotropin Secreting Cell Differentiation Thyroid-stimulating Hormone-secreting Cell Differentiation Mesenchymal To Epithelial Transition Tertiary Branching Involved In Mammary Gland Duct Morphogenesis Kidney Morphogenesis Negative Regulation Of Wound Healing Mammary Gland Epithelium Development Positive Regulation Of Dermatome Development Paramesonephric Duct Development Negative Regulation Of Testicular Blood Vessel Morphogenesis Cellular Response To Transforming Growth Factor Beta Stimulus Nephron Development Renal Vesicle Formation Renal Vesicle Induction Metanephric Mesenchymal Cell Differentiation Mesonephric Tubule Development Metanephric Tubule Formation Metanephric Nephron Development Metanephric Nephron Morphogenesis Apoptotic Signaling Pathway Meiotic Nuclear Division Pericyte Cell Differentiation Negative Regulation Of Male Gonad Development Positive Regulation Of Cortisol Biosynthetic Process Negative Regulation Of Androgen Biosynthetic Process Negative Regulation Of Testosterone Biosynthetic Process Negative Regulation Of Apoptotic Signaling Pathway
Pathways		TCF dependent signaling in response to WNT WNT ligand biogenesis and trafficking WNT ligand biogenesis and trafficking Class B/2 (Secretin family receptors) Negative regulation of TCF-dependent signaling by WNT ligand antagonists PCP/CE pathway PCP/CE pathway Nephron development
Drugs
Diseases		46,XX disorders of sex development (Other), including: Mullerian aplasia and hyperandrogenism; McKusick-Kaufman syndrome 46,XX disorders of sex development (Disorders of gonadal development), including: Ovotesticular DSD; Testicular DSD; Ovarian dysgenesis 46,XY disorders of sex development (Disorders of gonadal development), including: Gonadal agenesis; Complete and partial gonadal dysgenesis; Testis regression; Ovotesticular DSD
GWAS		Age-related cognitive decline (language) (slope of z-scores) ( 30954325) Appendicular lean mass ( 33097823) Birth weight ( 31043758 27680694) Bone mineral density (paediatric, lower limb) ( 24945404) Bone mineral density (paediatric, skull) ( 24945404) Bone mineral density (paediatric, total body less head) ( 28743860 24945404) Bone mineral density (paediatric, upper limb) ( 24945404) Bone mineral density (total hip) ( 29883787) Colorectal cancer ( 25990418) Daytime sleep phenotypes ( 27126917) Deep ovarian and/or rectovaginal disease with dense adhesions ( 28333195) Dupuytren's disease ( 21732829 28886342) Endometriosis ( 20601957 23472165 23104006 28333195 28537267) Epithelial ovarian cancer ( 25581431) Extremely high intelligence ( 29520040) Gestational age at birth (maternal effect) ( 28877031) Gynecologic disease ( 31488892) Gynecologic disease (multivariate analysis) ( 31488892) Heel bone mineral density ( 28869591 30598549) Height ( 28552196) Hip circumference adjusted for BMI ( 25673412 34021172) Hip index ( 34021172) Iron status biomarkers (ferritin levels) ( 33536631) Lumbar spine bone mineral density ( 22504420) Lumbar spine bone mineral density (integral) ( 27476799) Lumbar spine bone mineral density (trabecular) ( 27476799) Lung function in never smokers (low FEV1 vs high FEV1) ( 26423011) Metabolite levels ( 23823483) Obesity-related traits ( 23251661) Pelvic organ prolapse ( 32184442) Right-sided colonic diverticulosis ( 31089239) Spine bone size ( 31053729) Systolic blood pressure ( 30224653) TB-LM or TBLH-BMD (pleiotropy) ( 28743860) Thyroid stimulating hormone levels ( 32769997) Triglyceride levels ( 34074324) Uterine fibroids ( 31649266 31488892 31249589 30194396) Uterine fibroids (MTAG) ( 31488892) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Novel Interacting Genes		8 novel interacting genes: APP FZD6 LGALS3BP P2RX4 PORCN SFRP1 SFRP2 TMEM80
Interacting Genes		8 interacting genes: APP FZD6 LGALS3BP P2RX4 PORCN SFRP1 SFRP2 TMEM80
Entrez ID		54361
HPRD ID		04601
Ensembl ID		ENSG00000162552
Uniprot IDs		P56705
PDB IDs
Enriched GO Terms of Interacting Partners?		Wnt-protein Binding Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Wnt Signaling Pathway Involved In Somitogenesis Regulation Of Midbrain Dopaminergic Neuron Differentiation Non-canonical Wnt Signaling Pathway Development Of Primary Male Sexual Characteristics Regulation Of Canonical Wnt Signaling Pathway Convergent Extension Involved In Axis Elongation Wnt Signaling Pathway Regulation Of Establishment Of Planar Polarity Development Of Primary Sexual Characteristics Neural Tube Closure Regulation Of Wnt Signaling Pathway Cellular Response To X-ray Tube Closure Canonical Wnt Signaling Pathway Regulation Of Dopaminergic Neuron Differentiation Convergent Extension Tube Formation Negative Regulation Of Peptidyl-tyrosine Phosphorylation Digestive Tract Morphogenesis Regulation Of Extrinsic Apoptotic Signaling Pathway Cell Surface Receptor Signaling Pathway Response To X-ray Regulation Of Neuron Differentiation Wnt Signaling Pathway, Planar Cell Polarity Pathway Frizzled Binding Regulation Of Plasma Membrane Bounded Cell Projection Organization Positive Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Cell Projection Organization Positive Regulation Of Nitric Oxide Metabolic Process Neural Tube Development Negative Regulation Of Epithelial To Mesenchymal Transition Somitogenesis Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Segmentation Positive Regulation Of Calcium-mediated Signaling Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Nitric Oxide Biosynthetic Process Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Signal Transduction Regulation Of Nitric Oxide Metabolic Process Negative Regulation Of BMP Signaling Pathway Positive Regulation Of Fat Cell Differentiation Convergent Extension Involved In Somitogenesis
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