SOX18

Description		SRY-box transcription factor 18
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Transcription Regulator Complex
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Angiogenesis Blood Vessel Development Vasculogenesis In Utero Embryonic Development Hair Follicle Development Vasculature Development Lymph Vessel Development Lymphangiogenesis Heart Looping Outflow Tract Morphogenesis Regulation Of DNA-templated Transcription Heart Development Tissue Development Hair Cycle Process Embryonic Heart Tube Development Blood Vessel Endothelial Cell Migration Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Cell Maturation Anatomical Structure Formation Involved In Morphogenesis Stem Cell Fate Specification Endocardium Formation Lymphatic Endothelial Cell Differentiation Endocardial Cell Differentiation Establishment Of Endothelial Barrier Regulation Of Stem Cell Proliferation
Pathways
Drugs
Diseases		Lymphedemas, including: Lymphedema, hereditary I; Lymphedema-distichiasis syndrome (LD); Hypotrichosis-lymphedema-telangiectasia syndrome (HLTS)
GWAS		Cerebrospinal AB1-42 levels in normal cognition ( 29274321) Refractive error ( 32231278)
Novel Interacting Genes		5 novel interacting genes: AURKA GKAP1 HMGB1 MECP2 MEF2C
Interacting Genes		5 interacting genes: AURKA GKAP1 HMGB1 MECP2 MEF2C
Entrez ID		54345
HPRD ID		07208
Ensembl ID		ENSG00000203883
Uniprot IDs		P35713
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Endothelial Cell Migration Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Endothelial Cell Migration Regulation Of Cell Development Regulation Of Anatomical Structure Morphogenesis Positive Regulation Of Cell Differentiation Regulation Of Vascular Endothelial Cell Proliferation Negative Regulation Of Locomotion Negative Regulation Of Cell Migration Negative Regulation Of Gene Expression Negative Regulation Of Cell Motility Excitatory Postsynaptic Potential Positive Regulation Of Developmental Process Positive Regulation Of Cell Development Animal Organ Development Calcium-dependent Protein Kinase Regulator Activity Regulation Of Cell Differentiation Regulation Of Restriction Endodeoxyribonuclease Activity Regulation Of Apoptotic Process Positive Regulation Of Myeloid Progenitor Cell Differentiation Regulation Of Programmed Cell Death Regulation Of Cell Communication Regulation Of Signaling Regulation Of Postsynaptic Membrane Potential Sinoatrial Valve Morphogenesis Chromatin Remodeling Negative Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly Positive Regulation Of Cell Communication Positive Regulation Of Signaling Negative Regulation Of Apoptotic Cell Clearance Muscle Cell Fate Determination Nephron Tubule Epithelial Cell Differentiation Cellular Response To Trichostatin A Regulation Of Mismatch Repair C-X-C Chemokine Binding Plasma Membrane Bounded Cell Projection Organization Alphav-beta3 Integrin-HMGB1 Complex Chromatin Organization T-helper 1 Cell Activation Epithelial Cell Proliferation Positive Regulation Of Mismatch Repair Positive Regulation Of Lymphocyte Proliferation Plasmacytoid Dendritic Cell Activation Heterochromatin Formation Regulation Of Myeloid Progenitor Cell Differentiation Positive Regulation Of Glycogen Catabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Gene Expression, Epigenetic Cell Development
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