PLCD1

Description		phospholipase C delta 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Extracellular Exosome
	Molecular Function	Phosphatidylserine Binding Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity Phospholipase C Activity Calcium Ion Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Phosphoric Diester Hydrolase Activity Hydrolase Activity GTPase Activating Protein Binding Anion Binding Metal Ion Binding Phosphatidic Acid Binding Phosphatidylinositol Phospholipase C Activity Phosphatidylinositol Phosphate Binding
	Biological Process	Lipid Metabolic Process Phospholipid Metabolic Process Signal Transduction Lipid Catabolic Process Intracellular Signal Transduction Phosphatidylinositol Metabolic Process Phospholipase C/protein Kinase C Signal Transduction
Pathways		Synthesis of IP3 and IP4 in the cytosol
Drugs		1D-myo-inositol 1,4,5-trisphosphate Inositol 2,4,5-trisphosphate
Diseases
GWAS
Novel Interacting Genes		11 novel interacting genes: APP CALM1 GAP43 HGS KPNB1 NTAQ1 PAXIP1 RALA RALB TGM2 USP54
Interacting Genes		11 interacting genes: APP CALM1 GAP43 HGS KPNB1 NTAQ1 PAXIP1 RALA RALB TGM2 USP54
Entrez ID		5333
HPRD ID		09073
Ensembl ID		ENSG00000187091
Uniprot IDs		A0A384MR47 A8K8F9 P51178
PDB IDs
Enriched GO Terms of Interacting Partners?		Endocytosis Import Into Cell Axon Choice Point Recognition Receptor Internalization Vesicle-mediated Transport Response To Auditory Stimulus Cellular Response To Catecholamine Stimulus Response To Catecholamine Positive Regulation Of Signal Transduction Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Receptor-mediated Endocytosis Positive Regulation Of ERBB Signaling Pathway Regulation Of Vesicle-mediated Transport Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Positive Regulation Of Cell Communication Amylin Binding Positive Regulation Of Signaling Positive Regulation Of Toll Signaling Pathway Neuron Recognition Regulation Of Filopodium Assembly Regulation Of Exocyst Assembly Peptide Dopaminyltransferase Activity Histone Serotonyltransferase Activity Peptide Histaminyltransferase Activity Protein-glutamine Glutaminase Activity Peptide Noradrenalinyltransferase Activity Peptide Serotonyltransferase Activity Histone Dopaminyltransferase Activity Protein-N-terminal Glutamine Amidohydrolase Activity Synaptic Membrane Acetylcholine Receptor Activator Activity Regulation Of Signal Transduction G Protein-coupled Receptor Signaling Pathway Lipoprotein Particle Regulation Of Receptor Internalization Positive Regulation Of Protein Import Signal Transduction Extracellular Exosome Regulation Of Endocytosis Regulation Of Receptor Signaling Pathway Via JAK-STAT Negative Regulation Of High Voltage-gated Calcium Channel Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Establishment Of Protein Localization To Organelle ATPase Binding GDP Binding Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Edg-2 Lysophosphatidic Acid Receptor Binding G Protein Activity
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