PIK3CB

Description		phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Plasma Membrane Phosphatidylinositol 3-kinase Complex Phosphatidylinositol 3-kinase Complex, Class IA Midbody
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding Kinase Activity 1-phosphatidylinositol-3-kinase Activity Transferase Activity 1-phosphatidylinositol-4-phosphate 3-kinase Activity Insulin Receptor Substrate Binding 1-phosphatidylinositol-4,5-bisphosphate 3-kinase Activity Phosphatidylinositol Kinase Activity Protein Serine Kinase Activity
	Biological Process	Endothelial Cell Proliferation Regulation Of Cell-matrix Adhesion Leukocyte Mediated Immunity Response To Ischemia Sphingosine-1-phosphate Receptor Signaling Pathway Lipid Metabolic Process Intracellular Calcium Ion Homeostasis Endocytosis Autophagy Chemotaxis Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Autophagy Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Gene Expression Cell Migration Platelet Activation Positive Regulation Of Neutrophil Apoptotic Process Positive Regulation Of Rac Protein Signal Transduction Phosphatidylinositol-3-phosphate Biosynthetic Process Embryonic Cleavage Natural Killer Cell Mediated Cytotoxicity Negative Regulation Of MAPK Cascade Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Innate Immune Response Positive Regulation Of Nitric Oxide Biosynthetic Process Phosphatidylinositol Phosphate Biosynthetic Process Phosphatidylinositol-mediated Signaling Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Angiogenesis Involved In Wound Healing Platelet Aggregation Negative Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Negative Regulation Of Hypoxia-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Sprouting Angiogenesis Regulation Of Clathrin-dependent Endocytosis
Pathways		PI3K Cascade IRS-mediated signalling GPVI-mediated activation cascade PIP3 activates AKT signaling Synthesis of PIPs at the plasma membrane Downstream signal transduction PI3K/AKT activation Signaling by ALK Downstream TCR signaling Role of phospholipids in phagocytosis Tie2 Signaling Constitutive Signaling by Aberrant PI3K in Cancer DAP12 signaling Role of LAT2/NTAL/LAB on calcium mobilization Nephrin family interactions CD28 dependent PI3K/Akt signaling VEGFA-VEGFR2 Pathway VEGFA-VEGFR2 Pathway Interleukin-3, Interleukin-5 and GM-CSF signaling RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling RET signaling Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Interleukin receptor SHC signaling Regulation of signaling by CBL Regulation of signaling by CBL Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants Signaling by PDGFRA extracellular domain mutants Signaling by CSF1 (M-CSF) in myeloid cells Signaling by ALK fusions and activated point mutants Signaling by LTK in cancer Signaling by LTK High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells Co-stimulation by ICOS
Drugs		Caffeine XL765
Diseases
GWAS		Male-pattern baldness ( 28196072) Mean platelet volume ( 32888494)
Novel Interacting Genes		13 novel interacting genes: AGTR2 ALAS1 DVL3 HCK HPS6 LRRK2 MME PIK3R1 PIK3R2 PRKCD PRKCE RAB5B YWHAQ
Interacting Genes		13 interacting genes: AGTR2 ALAS1 DVL3 HCK HPS6 LRRK2 MME PIK3R1 PIK3R2 PRKCD PRKCE RAB5B YWHAQ
Entrez ID		5291
HPRD ID		04234
Ensembl ID		ENSG00000051382
Uniprot IDs		B4DER4 P42338
PDB IDs
Enriched GO Terms of Interacting Partners?		Intracellular Signaling Cassette Regulation Of Actin Cytoskeleton Organization Regulation Of Actin Filament-based Process Intracellular Signal Transduction Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc Receptor Mediated Stimulatory Signaling Pathway Regulation Of Actin Filament Organization Regulation Of Biological Quality Regulation Of Cytoskeleton Organization Exploration Behavior Regulation Of Actin Filament Polymerization Fc-gamma Receptor Signaling Pathway Response To Hormone Cellular Response To Hormone Stimulus Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Positive Regulation Of Protein Import Into Nucleus Diacylglycerol-dependent, Calcium-independent Serine/threonine Kinase Activity Regulation Of Transport Phosphotyrosine Residue Binding Regulation Of Supramolecular Fiber Organization Regulation Of Kidney Size Cellular Response To Peptide Hormone Stimulus 1-phosphatidylinositol-3-kinase Regulator Activity Regulation Of Organelle Organization Fc Receptor Signaling Pathway Regulation Of Protein-containing Complex Assembly Regulation Of Cellular Component Organization Regulation Of Protein Import Into Nucleus Positive Regulation Of Nucleocytoplasmic Transport Establishment Of Protein Localization Phosphatidylinositol 3-kinase Complex, Class IA Phosphatidylinositol 3-kinase Regulatory Subunit Binding Cellular Response To Oxygen-containing Compound Cell Surface Receptor Signaling Pathway Regulation Of Protein Localization Regulation Of Cellular Localization Positive Regulation Of Protein Transport Regulation Of Establishment Of Protein Localization Regulation Of Cellular Component Size Cellular Response To UV Regulation Of Intracellular Transport Positive Regulation Of Intracellular Protein Transport Insulin Receptor Substrate Binding Cellular Response To Insulin Stimulus Positive Regulation Of Protein Localization To Nucleus Locomotory Exploration Behavior Response To Peptide Hormone Cellular Response To Light Stimulus Protein Transport
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