PIGR

Description		polymeric immunoglobulin receptor
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Endomembrane System Membrane Cytoplasmic Vesicle Membrane Azurophil Granule Membrane Receptor Complex Extracellular Exosome Secretory IgA Immunoglobulin Complex Bounding Membrane Of Organelle
	Molecular Function	Polymeric Immunoglobulin Binding Polymeric Immunoglobulin Receptor Activity Transmembrane Signaling Receptor Activity
	Biological Process	Detection Of Chemical Stimulus Involved In Sensory Perception Of Bitter Taste Immunoglobulin Transcytosis In Epithelial Cells Mediated By Polymeric Immunoglobulin Receptor Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Fc Receptor Signaling Pathway Receptor Clustering
Pathways		Neutrophil degranulation
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Coronary atherosclerosis (increased number of diseased vessels) (traffic exposure interaction) ( 28355232) Inflammatory bowel disease ( 23128233) Metabolite levels ( 23823483) Precuneus cortex volume ( 31530798)
Novel Interacting Genes		4 novel interacting genes: AP1M1 CCL5 CD79A RAB3B
Interacting Genes		4 interacting genes: AP1M1 CCL5 CD79A RAB3B
Entrez ID		5284
HPRD ID		01436
Ensembl ID		ENSG00000162896
Uniprot IDs		P01833
PDB IDs		1XED 2OCW 3CHN 3CM9 5D4K 6KXS 6LX3 6LXW 6UE7 6UE8 6UE9 6UEA 7K0C 7YSG 8SKU 8SKV
Enriched GO Terms of Interacting Partners?		Chemokine Receptor Antagonist Activity Chemokine (C-C Motif) Ligand 5 Signaling Pathway CCR4 Chemokine Receptor Binding IgM B Cell Receptor Complex Immune System Process B Cell Receptor Complex Myosin V Binding Regulation Of Dopamine Uptake Involved In Synaptic Transmission GTP-dependent Protein Binding Secretion By Cell Positive Regulation Of Neurotransmitter Uptake Regulation Of Vesicle Size Vesicle-mediated Transport Dopaminergic Synapse Secretion Regulation Of Synaptic Vesicle Cycle Positive Regulation Of Dopamine Uptake Involved In Synaptic Transmission Regulation Of Neurotransmitter Uptake Exocytosis Negative Regulation Of T Cell Apoptotic Process Positive Regulation Of Cell-cell Adhesion Mediated By Integrin Positive Regulation Of Cell Adhesion Mediated By Integrin Receptor Signaling Protein Tyrosine Kinase Activator Activity Regulation Of Cell-cell Adhesion Mediated By Integrin Eosinophil Migration Positive Regulation Of Natural Killer Cell Chemotaxis Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity Negative Regulation Of Macrophage Apoptotic Process Macrophage Chemotaxis Eosinophil Chemotaxis Positive Regulation Of Neuroinflammatory Response Dendritic Cell Migration Phospholipase Activator Activity Dendritic Cell Chemotaxis Positive Regulation Of Lymphocyte Apoptotic Process Positive Regulation Of T Cell Chemotaxis Negative Regulation Of Myeloid Cell Apoptotic Process Host-mediated Suppression Of Viral Transcription Positive Regulation Of Homotypic Cell-cell Adhesion Macrophage Migration Monocyte Chemotaxis Negative Regulation Of Chemokine-mediated Signaling Pathway Regulation Of Chronic Inflammatory Response Regulation Of Lymphocyte Chemotaxis Positive Regulation Of Monocyte Chemotaxis Positive Regulation Of Lymphocyte Chemotaxis Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway CCR1 Chemokine Receptor Binding Positive Regulation Of T Cell Apoptotic Process Host-mediated Suppression Of Viral Proces
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