SERPINE2

Description		serpin family E member 2
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytosol Extracellular Matrix Platelet Alpha Granule Neuromuscular Junction Extracellular Vesicle
	Molecular Function	Serine-type Endopeptidase Inhibitor Activity Signaling Receptor Binding Protein Binding Glycosaminoglycan Binding Heparin Binding Peptidase Inhibitor Activity
	Biological Process	Nervous System Development Blood Coagulation Negative Regulation Of Cell Population Proliferation Response To Wounding Negative Regulation Of Platelet Activation Negative Regulation Of Plasminogen Activation Negative Regulation Of Sodium Ion Transport Negative Regulation Of Protein Processing Cerebellar Granular Layer Morphogenesis Cell Differentiation Protein Catabolic Process Platelet Activation Negative Regulation Of Blood Coagulation Negative Regulation Of Cell Growth Regulation Of Cell Migration Secretion By Cell Secretory Granule Organization Negative Regulation Of Protein Catabolic Process Mating Plug Formation Negative Regulation Of Proteolysis Negative Regulation Of Smoothened Signaling Pathway Regulation Of Timing Of Cell Differentiation Positive Regulation Of Astrocyte Differentiation Detection Of Mechanical Stimulus Involved In Sensory Perception Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Synaptic Transmission, Glutamatergic Long-term Synaptic Potentiation Innervation Seminal Vesicle Epithelium Development Negative Regulation Of Platelet Aggregation
Pathways		Intrinsic Pathway of Fibrin Clot Formation Common Pathway of Fibrin Clot Formation Dissolution of Fibrin Clot
Drugs
Diseases
GWAS		Adverse response to chemotherapy (neutropenia/leucopenia) (5-fluorouracil) ( 23648065) Blood protein levels ( 30072576) Cerebrospinal T-tau levels ( 28247064) Cytokine levels ( 31679650) Cytokine network levels (multivariate analysis) ( 31679650) Height ( 20881960 31562340) Inflammatory biomarkers (multivariate analysis) ( 33110245) Mean platelet volume ( 27863252 32888494) Platelet-derived growth factor BB levels ( 27989323)
Novel Interacting Genes		9 novel interacting genes: COL4A1 COL4A2 COL4A3 COL4A4 COL4A5 COL4A6 ETS2 F2 FAM9B
Interacting Genes		9 interacting genes: COL4A1 COL4A2 COL4A3 COL4A4 COL4A5 COL4A6 ETS2 F2 FAM9B
Entrez ID		5270
HPRD ID		01510
Ensembl ID		ENSG00000135919
Uniprot IDs		P07093
PDB IDs		4DY0 4DY7
Enriched GO Terms of Interacting Partners?		Collagen Type IV Trimer Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Extracellular Matrix Structural Constituent Conferring Tensile Strength Collagen-activated Signaling Pathway Collagen Trimer Basement Membrane Extracellular Matrix Structural Constituent Endoplasmic Reticulum Lumen Extracellular Matrix Extracellular Structure Organization Extracellular Matrix Organization Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Extracellular Region Glomerular Basement Membrane Development Cell Surface Receptor Signaling Pathway Neuromuscular Junction Development Cellular Response To Amino Acid Stimulus Ectodermal Cell Fate Commitment Response To Amino Acid Negative Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Thrombospondin Receptor Activity Neutrophil-mediated Killing Of Gram-negative Bacterium Retinal Blood Vessel Morphogenesis Positive Regulation Of Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway
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