ATP6V1B2

Description		ATPase H+ transporting V1 subunit B2
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GO Annotations	Cellular Component	Vacuolar Proton-transporting V-type ATPase, V1 Domain Ruffle Cytoplasm Lysosomal Membrane Cytosol Plasma Membrane Microvillus Membrane Apical Plasma Membrane Clathrin-coated Vesicle Membrane Synaptic Vesicle Membrane Cytoplasmic Vesicle Proton-transporting V-type ATPase, V1 Domain Melanosome Synapse Extracellular Exosome Extrinsic Component Of Synaptic Vesicle Membrane
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding Proton Transmembrane Transporter Activity Proton-transporting ATPase Activity, Rotational Mechanism
	Biological Process	Monoatomic Ion Transport Vacuolar Acidification Regulation Of Macroautophagy ATP Metabolic Process Synaptic Vesicle Lumen Acidification Proton Transmembrane Transport
Pathways		ROS and RNS production in phagocytes Insulin receptor recycling Transferrin endocytosis and recycling Amino acids regulate mTORC1 Ion channel transport Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy
Drugs		Tiludronic acid Gallium nitrate 4-(2-Aminoethyl)Benzenesulfonyl Fluoride
Diseases
GWAS		Circulating myeloperoxidase levels (serum) ( 23620142) Erythrocyte cadmium concentration in never smokers ( 27005419) Major depressive disorder (broad) ( 20038947) Metabolite levels ( 23823483) Persistent hepatitis B virus infection ( 27244555)
Novel Interacting Genes		3 novel interacting genes: DSCAM LCOR TCF4
Interacting Genes		3 interacting genes: DSCAM LCOR TCF4
Entrez ID		526
HPRD ID		06088
Ensembl ID		ENSG00000147416
Uniprot IDs		A0A140VK65 P21281
PDB IDs		6WLZ 6WM2 6WM3 6WM4 7U4T 7UNF
Enriched GO Terms of Interacting Partners?		Post-embryonic Retina Morphogenesis In Camera-type Eye Positive Regulation Of Axon Extension Involved In Axon Guidance Netrin Receptor Binding TFIIB-class Transcription Factor Binding Beta-catenin-TCF7L2 Complex Netrin-activated Signaling Pathway Regulation Of Axon Extension Involved In Axon Guidance Dendrite Self-avoidance Camera-type Eye Photoreceptor Cell Differentiation Eye Photoreceptor Cell Differentiation Dendritic Spine Development Nervous System Development Photoreceptor Cell Differentiation Beta-catenin-TCF Complex Histone Methyltransferase Binding Ubiquitin-specific Protease Binding
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