PHKA1

Description		phosphorylase kinase regulatory subunit alpha 1
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Phosphorylase Kinase Complex Membrane
	Molecular Function	Phosphorylase Kinase Activity Protein Binding Calmodulin Binding
	Biological Process	Carbohydrate Metabolic Process Glycogen Metabolic Process Generation Of Precursor Metabolites And Energy Positive Regulation Of Glycogen Catabolic Process
Pathways		Glycogen breakdown (glycogenolysis) Glycogen breakdown (glycogenolysis)
Drugs
Diseases		Glycogen storage diseases (GSD), including: von Gierke disease (GSD type Ia); Pompe disease (GSD type II); Cori disease, Forbe disease (GSD type III); Andersen disease (GSD type IV); McArdle disease (GSD type V); Hers disease (GSD type VI); Tarui disease (GSD type VII); Phosphorylase kinase deficiency (GSD type IX); Fanconi-Bickel syndrome (GSD type XI); Glycogen synthase deficiency (GSD type 0)
GWAS
Novel Interacting Genes		3 novel interacting genes: PIGO PRKACA TUBGCP4
Interacting Genes		3 interacting genes: PIGO PRKACA TUBGCP4
Entrez ID		5255
HPRD ID		02415
Ensembl ID		ENSG00000067177
Uniprot IDs		A6NMN0 P46020
PDB IDs		8JFK 8JFL 8XY7 8XYA 8XYB
Enriched GO Terms of Interacting Partners?		CAMP-dependent Protein Kinase Complex Protein-lipid Complex Assembly Protein Serine/threonine/tyrosine Kinase Activity Regulation Of Cardiac Conduction Vascular Endothelial Cell Response To Fluid Shear Stress Cellular Response To Parathyroid Hormone Stimulus Negative Regulation Of Glycolytic Process Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Cellular Response To Glucagon Stimulus Centrosome Negative Regulation Of Interleukin-2 Production Response To Laminar Fluid Shear Stress Sperm Capacitation CAMP-dependent Protein Kinase Activity Interleukin-2-mediated Signaling Pathway Calcium Channel Complex Cellular Response To Laminar Fluid Shear Stress Negative Regulation Of ATP Metabolic Process Plasma Lipoprotein Particle Assembly Regulation Of Bicellular Tight Junction Assembly Cellular Response To Epinephrine Stimulus Multicellular Organismal-level Water Homeostasis Positive Regulation Of Cholesterol Biosynthetic Process Cell Communication By Electrical Coupling High-density Lipoprotein Particle Assembly Negative Regulation Of Glycolytic Process Through Fructose-6-phosphate Renal Water Homeostasis Response To Parathyroid Hormone Positive Regulation Of Gluconeogenesis Response To Glucagon Positive Regulation Of Protein Export From Nucleus Cellular Response To Cold Cell Communication By Electrical Coupling Involved In Cardiac Conduction Protein Localization To Lipid Droplet Intracellular Potassium Ion Homeostasis Protein Kinase A Regulatory Subunit Binding Mitochondrial Protein Catabolic Process Response To Epinephrine CAMP/PKA Signal Transduction Nucleotide-activated Protein Kinase Complex Channel Activator Activity Cell Communication Involved In Cardiac Conduction Vascular Endothelial Cell Response To Laminar Fluid Shear Stress Microtubule Minus-end Binding Gamma-tubulin Ring Complex Gamma-tubulin Complex Transferase Activity, Transferring Phosphorus-containing Groups Phosphotransferase Activity, For Other Substituted Phosphate Groups GPI Anchor Metabolic Process Mannose-ethanolamine Phosphotransferase Activity
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