PGGT1B

Description		protein geranylgeranyltransferase type I subunit beta
Image		No pdb structure
GO Annotations	Cellular Component	CAAX-protein Geranylgeranyltransferase Complex
	Molecular Function	Catalytic Activity Prenyltransferase Activity Protein Geranylgeranyltransferase Activity CAAX-protein Geranylgeranyltransferase Activity Protein Binding Zinc Ion Binding Protein Prenyltransferase Activity Transferase Activity Metal Ion Binding
	Biological Process	Protein Geranylgeranylation
Pathways
Drugs		L-778123 Geranylgeranyl diphosphate 2-[METHYL-(5-GERANYL-4-METHYL-PENT-3-ENYL)-AMINO]-ETHYL-DIPHOSPHATE
Diseases
GWAS		Longevity ( 30294719)
Novel Interacting Genes		6 novel interacting genes: CDC42 FNTA GNG2 KRAS RHOB RRAS2
Interacting Genes		6 interacting genes: CDC42 FNTA GNG2 KRAS RHOB RRAS2
Entrez ID		5229
HPRD ID		03612
Ensembl ID		ENSG00000164219
Uniprot IDs		P53609
PDB IDs
Enriched GO Terms of Interacting Partners?		GDP Binding GTPase Activity Small GTPase-mediated Signal Transduction GTP Binding Focal Adhesion Positive Regulation Of Rac Protein Signal Transduction Regulation Of Rac Protein Signal Transduction Intracellular Signaling Cassette Signal Transduction G Protein Activity Positive Regulation Of Small GTPase Mediated Signal Transduction Plasma Membrane Peptide Pheromone Maturation Ras Protein Signal Transduction Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility GBD Domain Binding Storage Vacuole CAAX-protein Geranylgeranyltransferase Activity CAAX-protein Geranylgeranyltransferase Complex Protein Farnesyltransferase Activity Protein Farnesyltransferase Complex Positive Regulation Of Locomotion Endothelin Receptor Signaling Pathway Involved In Heart Process Golgi Membrane Protein Farnesylation GMP Binding Forebrain Astrocyte Development Positive Regulation Of Schwann Cell Migration Schwann Cell Migration Nucleotide Binding Apolipoprotein A-I Receptor Binding Neuropilin Signaling Pathway Rab Geranylgeranyltransferase Activity Protein Geranylgeranyltransferase Activity Response To Isolation Stress Intracellular Signal Transduction Protein Prenyltransferase Activity Protein Geranylgeranylation LRR Domain Binding Positive Regulation Of Pinocytosis G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Positive Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Response To Gravity Extracellular Exosome Regulation Of Cell Migration Actin Filament Organization Leading Edge Membrane Thioesterase Binding
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