PFKFB2

Description		6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2
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GO Annotations	Cellular Component	Nucleoplasm Cytosol 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase Complex
	Molecular Function	Nucleotide Binding Catalytic Activity 6-phosphofructo-2-kinase Activity Fructose-2,6-bisphosphate 2-phosphatase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Hydrolase Activity Kinase Binding Protein Kinase Binding
	Biological Process	Fructose Metabolic Process Fructose 2,6-bisphosphate Metabolic Process Glucose Catabolic Process Lactate Metabolic Process Gluconeogenesis Glycolytic Process Response To Glucose Positive Regulation Of Insulin Secretion Carbohydrate Phosphorylation
Pathways		Regulation of glycolysis by fructose 2,6-bisphosphate metabolism
Drugs
Diseases
GWAS		Diastolic blood pressure ( 30224653) Estimated glomerular filtration rate ( 31152163) White blood cell count ( 32888494)
Novel Interacting Genes		9 novel interacting genes: AKT1 GCK PRKAA1 PRKAA2 PRKACA PRKCA YWHAG YWHAQ YWHAZ
Interacting Genes		9 interacting genes: AKT1 GCK PRKAA1 PRKAA2 PRKACA PRKCA YWHAG YWHAQ YWHAZ
Entrez ID		5208
HPRD ID		01383
Ensembl ID		ENSG00000123836
Uniprot IDs		B0FLL2 O60825
PDB IDs		5HTK
Enriched GO Terms of Interacting Partners?		Negative Regulation Of TORC1 Signaling TORC1 Signaling TOR Signaling Negative Regulation Of TOR Signaling Regulation Of TORC1 Signaling Regulation Of TOR Signaling Protein Localization To Lipid Droplet Protein K6-linked Ubiquitination Regulation Of Protein Localization Cellular Response To Nutrient Levels Response To Hormone Regulation Of Generation Of Precursor Metabolites And Energy Cellular Response To Hormone Stimulus Negative Regulation Of Translational Initiation Positive Regulation Of Translational Initiation Positive Regulation Of Small Molecule Metabolic Process Cellular Response To Glucose Starvation Regulation Of Glycolytic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Translation Cellular Response To Starvation Nucleotide-activated Protein Kinase Complex Cellular Response To Amino Acid Starvation Response To Amino Acid Starvation Positive Regulation Of TORC1 Signaling Positive Regulation Of Protein Localization Regulation Of Carbohydrate Catabolic Process Carbohydrate Homeostasis Glucose Homeostasis Response To Nutrient Levels Response To Starvation Regulation Of ATP Metabolic Process Regulation Of Purine Nucleotide Metabolic Process Negative Regulation Of Metabolic Process Positive Regulation Of TOR Signaling Intracellular Glucose Homeostasis Cellular Response To Prostaglandin E Stimulus Regulation Of Phosphorus Metabolic Process Intracellular Signal Transduction Positive Regulation Of Cholesterol Biosynthetic Process Kinase Activity Regulation Of Translational Initiation Response To Peptide Hormone Cellular Response To Prostaglandin Stimulus Histone H2BS36 Kinase Activity [hydroxymethylglutaryl-CoA Reductase (NADPH)] Kinase Activity Response To Prostaglandin E Regulation Of Small Molecule Metabolic Process Cytoplasmic Translation Protein Serine/threonine/tyrosine Kinase Activity
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