PEX6

Description		peroxisomal biogenesis factor 6
Image		No pdb structure
GO Annotations	Cellular Component	Photoreceptor Outer Segment Cytoplasm Peroxisome Peroxisomal Membrane Cytosol Membrane Cell Projection Photoreceptor Cell Cilium
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Protein-containing Complex Binding Ubiquitin-modified Protein Reader Activity Protein Transporter Activity
	Biological Process	Protein Targeting To Peroxisome Peroxisome Organization Protein Import Into Peroxisome Matrix Protein Import Into Peroxisome Matrix, Translocation Protein Import Into Peroxisome Matrix, Receptor Recycling Protein Unfolding Protein Stabilization
Pathways		Peroxisomal protein import Peroxisomal protein import
Drugs
Diseases		Zellweger syndrome spectrum, including: Zellweger syndrome (ZS); Adrenoleukodystrophy, neonatal (NALD); Infantile Refsum disease (IRD)
GWAS		Alzheimer's disease in APOE e4+ carriers ( 25778476) Hematocrit ( 32888494) Red blood cell count ( 32888494)
Novel Interacting Genes		9 novel interacting genes: ATF7IP CERS2 NFKBIE PEX1 PEX26 PEX5 RPL27A RPS14 SMAD3
Interacting Genes		9 interacting genes: ATF7IP CERS2 NFKBIE PEX1 PEX26 PEX5 RPL27A RPS14 SMAD3
Entrez ID		5190
HPRD ID		03293
Ensembl ID		ENSG00000124587
Uniprot IDs		Q13608
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Import Into Peroxisome Matrix Protein Import Into Peroxisome Matrix, Receptor Recycling Protein Unfolding Establishment Of Protein Localization To Peroxisome Peroxisomal Membrane Transport Peroxisome Organization Receptor Recycling Intracellular Protein Transmembrane Transport Receptor Metabolic Process Protein Import Into Peroxisome Membrane Peroxisomal Membrane Protein Transmembrane Transport Protein Targeting To Peroxisome Peroxisome Negative Regulation Of Lung Blood Pressure Nuclear Mineralocorticoid Receptor Binding Negative Regulation Of Schwann Cell Proliferation Involved In Axon Regeneration Cytosol Establishment Of Protein Localization To Organelle Positive Regulation Of Transforming Growth Factor Beta3 Production Microtubule-based Peroxisome Localization Peroxisome Membrane Targeting Sequence Binding Peroxisome Matrix Targeting Signal-1 Binding Cytosolic Ribosome Sterol Response Element Binding Paraxial Mesoderm Morphogenesis Peroxisome Targeting Sequence Binding Negative Regulation Of Schwann Cell Migration Cytoplasmic Translation Regulation Of Lung Blood Pressure Protein Import Into Peroxisome Matrix, Translocation Protein Import Into Peroxisome Matrix, Docking Intracellular Protein Transport Mesoderm Morphogenesis Immune System Development Structural Constituent Of Ribosome Protein To Membrane Docking Pericardium Development Protein Import Into Peroxisome Matrix, Substrate Release Sphingosine N-acyltransferase Activity Transdifferentiation SMAD Protein Complex Trophoblast Cell Migration Regulation Of Response To Wounding Protein Localization To Organelle Negative Regulation Of Glial Cell Migration DEAD/H-box RNA Helicase Binding Heteromeric SMAD Protein Complex Regulation Of Transforming Growth Factor Beta2 Production Ribosome
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