TUBA8

Description		tubulin alpha 8
Image		No pdb structure
GO Annotations	Cellular Component	Acrosomal Vesicle Cytoplasm Cytoskeleton Microtubule Microtubule Cytoskeleton
	Molecular Function	Nucleotide Binding Structural Constituent Of Cytoskeleton Protein Binding GTP Binding Hydrolase Activity Metal Ion Binding
	Biological Process	Microtubule Cytoskeleton Organization Mitotic Cell Cycle Microtubule-based Process Spermatogenesis Spermatid Development
Pathways		Translocation of SLC2A4 (GLUT4) to the plasma membrane Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane Gap junction assembly MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Recruitment of NuMA to mitotic centrosomes Formation of tubulin folding intermediates by CCT/TriC Post-chaperonin tubulin folding pathway Recycling pathway of L1 Recycling pathway of L1 Cargo trafficking to the periciliary membrane RHO GTPases activate IQGAPs RHO GTPases Activate Formins COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase The role of GTSE1 in G2/M progression after G2 checkpoint Carboxyterminal post-translational modifications of tubulin Carboxyterminal post-translational modifications of tubulin HCMV Early Events Assembly and cell surface presentation of NMDA receptors Activation of AMPK downstream of NMDARs Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation Sealing of the nuclear envelope (NE) by ESCRT-III Kinesins PKR-mediated signaling
Drugs		Epothilone D Patupilone
Diseases
GWAS		Atrial fibrillation ( 29892015 30061737) Cerebrospinal T-tau levels ( 28247064)
Novel Interacting Genes		10 novel interacting genes: CCT8L2 FOXP1 GRM7 LINC01554 MYC POTEH PXN SIAH1 TCP1 TCP11L2
Interacting Genes		10 interacting genes: CCT8L2 FOXP1 GRM7 LINC01554 MYC POTEH PXN SIAH1 TCP1 TCP11L2
Entrez ID		51807
HPRD ID		05763
Ensembl ID		ENSG00000183785
Uniprot IDs		Q9NY65
PDB IDs
Enriched GO Terms of Interacting Partners?		Chaperonin-containing T-complex Core Promoter Sequence-specific DNA Binding Regulation Of Monocyte Differentiation Regulation Of B Cell Apoptotic Process ATP-dependent Protein Folding Chaperone Regulation Of Lymphocyte Apoptotic Process Positive Regulation Of Metanephric Cap Mesenchymal Cell Proliferation Acinar Cell Proliferation Positive Regulation Of Acinar Cell Proliferation SCF Ubiquitin Ligase Complex Binding Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Telomere Maintenance Group III Metabotropic Glutamate Receptor Activity Myc-Max Complex Regulation Of Acinar Cell Proliferation Positive Regulation Of Interleukin-21 Production
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