SLC26A4

Description		solute carrier family 26 member 4
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Apical Plasma Membrane Brush Border Membrane Extracellular Exosome
	Molecular Function	Protein Binding Secondary Active Sulfate Transmembrane Transporter Activity Chloride Transmembrane Transporter Activity Iodide Transmembrane Transporter Activity Sulfate Transmembrane Transporter Activity Oxalate Transmembrane Transporter Activity Chloride:bicarbonate Antiporter Activity
	Biological Process	Monoatomic Ion Transport Regulation Of PH Sensory Perception Of Sound Inorganic Anion Transport Iodide Transport Oxalate Transport Regulation Of Protein Localization Transmembrane Transport Sulfate Transmembrane Transport Chloride Transmembrane Transport
Pathways		Inorganic anion exchange by SLC26 transporters Defective SLC26A4 causes Pendred syndrome (PDS)
Drugs
Diseases		Deafness, autosomal recessive Thyroid dyshormonogenesis; Dyshormogenetic goiter
GWAS		Alcohol consumption ( 23743675) Serum alkaline phosphatase levels ( 29403010) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Novel Interacting Genes		1 novel interacting genes: MET
Interacting Genes		1 interacting genes: MET
Entrez ID		5172
HPRD ID		05735
Ensembl ID		ENSG00000091137
Uniprot IDs		O43511
PDB IDs
Enriched GO Terms of Interacting Partners?		Hepatocyte Growth Factor Receptor Activity Negative Regulation Of Thrombin-activated Receptor Signaling Pathway Negative Regulation Of Guanyl-nucleotide Exchange Factor Activity Positive Regulation Of Endothelial Cell Chemotaxis Semaphorin Receptor Activity Endothelial Cell Morphogenesis Negative Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Hepatocyte Growth Factor Receptor Signaling Pathway Negative Regulation Of Rho Protein Signal Transduction Pancreas Development Molecular Function Activator Activity Negative Regulation Of Actin Filament Bundle Assembly Positive Regulation Of Microtubule Polymerization Epithelial Cell Morphogenesis Establishment Of Skin Barrier Negative Regulation Of Stress Fiber Assembly Skin Epidermis Development Semaphorin-plexin Signaling Pathway Positive Chemotaxis Positive Regulation Of Binding Transmembrane Receptor Protein Tyrosine Kinase Activity Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Microtubule Polymerization Negative Regulation Of Small GTPase Mediated Signal Transduction Basal Plasma Membrane Excitatory Postsynaptic Potential Positive Regulation Of Protein Polymerization Regulation Of Microtubule Polymerization Or Depolymerization Negative Regulation Of Autophagy Protein Phosphatase Binding Regulation Of Stress Fiber Assembly Regulation Of Rho Protein Signal Transduction Liver Development Regulation Of Postsynaptic Membrane Potential Positive Regulation Of Endothelial Cell Migration Branching Morphogenesis Of An Epithelial Tube Protein Tyrosine Kinase Activity Regulation Of GTPase Activity Positive Regulation Of Chemotaxis Epidermis Development Negative Regulation Of Cytoskeleton Organization Negative Regulation Of Supramolecular Fiber Organization Morphogenesis Of A Branching Epithelium Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Microtubule Cytoskeleton Organization Morphogenesis Of A Branching Structure Positive Regulation Of Supramolecular Fiber Organization Regulation Of Endothelial Cell Migration Receptor Complex Positive Regulation Of Cytoskeleton Organization
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