PDK1

Description		pyruvate dehydrogenase kinase 1
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix Pyruvate Dehydrogenase Complex
	Molecular Function	Nucleotide Binding Protein Kinase Activity Pyruvate Dehydrogenase (acetyl-transferring) Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity
	Biological Process	Glucose Metabolic Process Cell Population Proliferation Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Regulation Of Pyruvate Decarboxylation To Acetyl-CoA Regulation Of Glucose Metabolic Process Cellular Response To Stress Hypoxia-inducible Factor-1alpha Signaling Pathway
Pathways		Regulation of pyruvate dehydrogenase (PDH) complex Signaling by Retinoic Acid Mitochondrial protein degradation
Drugs		4-[(3-CHLORO-4-{[(2R)-3,3,3-TRIFLUORO-2-HYDROXY-2-METHYLPROPANOYL]AMINO}PHENYL)SULFONYL]-N,N-DIMETHYLBENZAMIDE Dichloroacetic acid
Diseases
GWAS		Erectile dysfunction in type 1 diabetes ( 22704111) Fasting plasma glucose ( 25187374)
Novel Interacting Genes		17 novel interacting genes: AKT1 BIN1 COL6A1 DLAT FGFR1 ITGB3 KAT2B LAMTOR5 PDHA1 PDK2 PIK3CA RPS6KB1 SGK1 UBE2O USP4 XRCC6 YWHAQ
Interacting Genes		17 interacting genes: AKT1 BIN1 COL6A1 DLAT FGFR1 ITGB3 KAT2B LAMTOR5 PDHA1 PDK2 PIK3CA RPS6KB1 SGK1 UBE2O USP4 XRCC6 YWHAQ
Entrez ID		5163
HPRD ID		03954
Ensembl ID		ENSG00000152256
Uniprot IDs		B7Z207 B7Z7N6 Q15118
PDB IDs		2Q8F 2Q8G 2Q8H
Enriched GO Terms of Interacting Partners?		Glucose Metabolic Process Monosaccharide Metabolic Process Hexose Metabolic Process Positive Regulation Of TOR Signaling Insulin Receptor Signaling Pathway Pyruvate Dehydrogenase Complex Carbohydrate Metabolic Process Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of TOR Signaling Positive Regulation Of TORC1 Signaling TORC1 Signaling Cellular Response To Hormone Stimulus Cellular Response To Peptide Hormone Stimulus TOR Signaling Intracellular Signal Transduction Enzyme-linked Receptor Protein Signaling Pathway Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Phosphatidylinositol-mediated Signaling Regulation Of TORC1 Signaling Cellular Response To Insulin Stimulus Protein Serine/threonine/tyrosine Kinase Activity Regulation Of Programmed Cell Death Tricarboxylic Acid Cycle Cellular Response To Nutrient Levels Insulin-like Growth Factor Receptor Signaling Pathway Protein-containing Complex Cellular Response To Nutrient Response To Peptide Hormone Cellular Response To Oxygen-containing Compound Transferase Activity Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Translational Initiation Response To Hormone Phosphate-containing Compound Metabolic Process Response To Insulin Kinase Activity Pyruvate Decarboxylation To Acetyl-CoA ATP Binding Regulation Of Apoptotic Process Small Molecule Metabolic Process Negative Regulation Of TORC1 Signaling Regulation Of Intracellular Signal Transduction Pyruvate Metabolic Process Regulation Of Biological Quality Organic Acid Metabolic Process Response To Ketone Anoikis Positive Regulation Of Intracellular Signal Transduction Response To Activity Positive Regulation Of Signal Transduction
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