PDHA2

Description		pyruvate dehydrogenase E1 subunit alpha 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleolus Mitochondrion Mitochondrial Matrix Pyruvate Dehydrogenase Complex
	Molecular Function	Pyruvate Dehydrogenase (acetyl-transferring) Activity Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On The Aldehyde Or Oxo Group Of Donors, Disulfide As Acceptor Metal Ion Binding
	Biological Process	Glucose Metabolic Process Pyruvate Decarboxylation To Acetyl-CoA Tricarboxylic Acid Cycle
Pathways		Regulation of pyruvate dehydrogenase (PDH) complex Signaling by Retinoic Acid PDH complex synthesizes acetyl-CoA from PYR
Drugs		NADH
Diseases
GWAS		Disease progression in age-related macular degeneration (adjusted for baseline) ( 29346644) Metabolite levels ( 23823483) Triacylglyceride levels ( 31551469)
Novel Interacting Genes		2 novel interacting genes: MEOX2 PDHB
Interacting Genes		2 interacting genes: MEOX2 PDHB
Entrez ID		5161
HPRD ID		01531
Ensembl ID		ENSG00000163114
Uniprot IDs		P29803
PDB IDs
Enriched GO Terms of Interacting Partners?		Somite Specification Pyruvate Decarboxylation To Acetyl-CoA Pyruvate Dehydrogenase Complex Pyruvate Dehydrogenase (acetyl-transferring) Activity Segment Specification Somite Development Acetyl-CoA Biosynthetic Process Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Acetyl-CoA Metabolic Process Tricarboxylic Acid Cycle Regulation Of Cell Migration Involved In Sprouting Angiogenesis Limb Development Negative Regulation Of Blood Vessel Endothelial Cell Migration Embryonic Pattern Specification Skeletal Muscle Tissue Development Pyruvate Metabolic Process Negative Regulation Of Endothelial Cell Migration
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