PDE8A

Description		phosphodiesterase 8A
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GO Annotations	Cellular Component	Cytosol Extracellular Exosome
	Molecular Function	3',5'-cyclic-nucleotide Phosphodiesterase Activity 3',5'-cyclic-AMP Phosphodiesterase Activity Phosphoric Diester Hydrolase Activity Hydrolase Activity Kinase Binding Protein Kinase Activator Activity Metal Ion Binding 3',5'-cyclic-GMP Phosphodiesterase Activity
	Biological Process	CAMP Catabolic Process Regulation Of DNA-templated Transcription Signal Transduction Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Epidermal Growth Factor Stimulus Negative Regulation Of CAMP/PKA Signal Transduction
Pathways		G alpha (s) signalling events
Drugs		Caffeine 3-isobutyl-1-methyl-7H-xanthine Trapidil
Diseases
GWAS		Bulimia nervosa ( 23568457) Central corneal thickness ( 20719862) Heel bone mineral density ( 30598549) Height ( 31562340) Hip circumference adjusted for BMI ( 34021172) Medication use (diuretics) ( 31015401) Neurofibrillary tangles ( 31497858) Systolic blood pressure ( 30224653 30578418) Testicular germ cell tumor ( 28604728) Waist circumference adjusted for body mass index ( 34021172)
Novel Interacting Genes		1 novel interacting genes: SEC11A
Interacting Genes
Entrez ID		5151
HPRD ID		09114
Ensembl ID		ENSG00000073417
Uniprot IDs		O60658
PDB IDs		3ECM 3ECN 7CWA 7CWF 7CWG 7VSL 7VTV 7VTW 7VTX
Enriched GO Terms of Interacting Partners?		Signal Peptidase Complex Signal Peptide Processing
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