PDE3B

Description		phosphodiesterase 3B
Image
GO Annotations	Cellular Component	Endoplasmic Reticulum Golgi Apparatus Cytosol Membrane Guanyl-nucleotide Exchange Factor Complex
	Molecular Function	3',5'-cyclic-nucleotide Phosphodiesterase Activity 3',5'-cyclic-AMP Phosphodiesterase Activity Protein Binding Phosphoric Diester Hydrolase Activity Hydrolase Activity Protein Kinase B Binding Metal Ion Binding 3',5'-cyclic-GMP Phosphodiesterase Activity
	Biological Process	Angiogenesis Negative Regulation Of Cell Adhesion Signal Transduction G Protein-coupled Receptor Signaling Pathway Insulin Receptor Signaling Pathway Negative Regulation Of Angiogenesis Negative Regulation Of Cell Adhesion Mediated By Integrin Regulation Of Angiogenesis Negative Regulation Of Lipid Catabolic Process Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Negative Regulation Of CAMP/PKA Signal Transduction
Pathways		PDE3B signalling PDE3B signalling G alpha (s) signalling events
Drugs		Caffeine Caffeine Papaverine Amrinone 6-(4-{[2-(3-iodobenzyl)-3-oxocyclohex-1-en-1-yl]amino}phenyl)-5-methyl-4,5-dihydropyridazin-3(2H)-one Hg9a-9, Nonanoyl-N-Hydroxyethylglucamide 3-isobutyl-1-methyl-7H-xanthine Trapidil
Diseases
GWAS		Adiponectin levels ( 31178129) Bipolar disorder ( 31043756) Femur bone mineral density x serum urate levels interaction ( 34046847) HDL cholesterol ( 30275531) High density lipoprotein cholesterol levels ( 29083408) High light scatter reticulocyte count ( 32888494) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Mean spheric corpuscular volume ( 32888494) Multiple sclerosis ( 31604244) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Serum 25-Hydroxyvitamin D levels ( 31841498) Triglyceride levels ( 32203549) Triglycerides ( 30275531) Type 2 diabetes ( 30297969) Vitamin D levels ( 25208829) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) Waist-to-hip ratio adjusted for body mass index ( 28430825)
Novel Interacting Genes		7 novel interacting genes: AKT1 ANKRA2 HPGDS LNX1 PRKACA YWHAB YWHAQ
Interacting Genes		7 interacting genes: AKT1 ANKRA2 HPGDS LNX1 PRKACA YWHAB YWHAQ
Entrez ID		5140
HPRD ID		03626
Ensembl ID		ENSG00000152270
Uniprot IDs		A7E2E5 Q13370
PDB IDs		1SO2 1SOJ 8SYC
Enriched GO Terms of Interacting Partners?		Vascular Endothelial Cell Response To Laminar Fluid Shear Stress Vascular Endothelial Cell Response To Fluid Shear Stress Response To Laminar Fluid Shear Stress Cellular Response To Laminar Fluid Shear Stress Positive Regulation Of Cholesterol Biosynthetic Process Protein Serine/threonine/tyrosine Kinase Activity Postsynapse Positive Regulation Of Cholesterol Metabolic Process Cellular Response To Fluid Shear Stress 14-3-3 Protein Binding Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Steroid Biosynthetic Process Protein Domain Specific Binding Peptidyl-serine Phosphorylation Protein-containing Complex Positive Regulation Of Steroid Metabolic Process Response To Fluid Shear Stress Positive Regulation Of Glucose Metabolic Process Regulation Of Cholesterol Metabolic Process Regulation Of Protein Maturation TORC1 Signaling Negative Regulation Of TORC1 Signaling Regulation Of TRNA Methylation Regulation Of Monoatomic Ion Transport Regulation Of Steroid Biosynthetic Process TOR Signaling Negative Regulation Of Transport Response To Heat Negative Regulation Of TOR Signaling Protein Kinase Binding Regulation Of TORC1 Signaling Regulation Of Glucose Metabolic Process Positive Regulation Of Lipid Biosynthetic Process Regulation Of Steroid Metabolic Process Negative Regulation Of Protein Localization To Lysosome Positive Regulation Of Protein Localization To Endoplasmic Reticulum Regulation Of Cellular Localization Establishment Of Protein Localization Response To Insulin-like Growth Factor Stimulus Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Mammalian Oogenesis Stage Negative Regulation Of Small Molecule Metabolic Process TRNA (guanine-N7)-methylation Cellular Response To Rapamycin Negative Regulation Of Hydrogen Peroxide-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Endodeoxyribonuclease Activity Regulation Of Generation Of Precursor Metabolites And Energy Negative Regulation Of Transmembrane Transport Regulation Of Nucleocytoplasmic Transport
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