EIF3L

Description		eukaryotic translation initiation factor 3 subunit L
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GO Annotations	Cellular Component	Fibrillar Center Nucleoplasm Nucleolus Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 3 Complex Membrane Eukaryotic 43S Preinitiation Complex Protein-containing Complex Eukaryotic 48S Preinitiation Complex Synapse
	Molecular Function	RNA Binding Translation Initiation Factor Activity Protein Binding
	Biological Process	Formation Of Cytoplasmic Translation Initiation Complex Cytoplasmic Translational Initiation Translation Translational Initiation Viral Translational Termination-reinitiation
Pathways		L13a-mediated translational silencing of Ceruloplasmin expression Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit
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Diseases
GWAS		Brain morphology (MOSTest) ( 32665545)
Novel Interacting Genes		13 novel interacting genes: DNM2 EIF3D EIF3E EIF3K ERCC6 HRAS POLR1B PPP1R18 RGS2 RRN3 SMAD2 SNCA XRN2
Interacting Genes		13 interacting genes: DNM2 EIF3D EIF3E EIF3K ERCC6 HRAS POLR1B PPP1R18 RGS2 RRN3 SMAD2 SNCA XRN2
Entrez ID		51386
HPRD ID		10932
Ensembl ID		ENSG00000100129
Uniprot IDs		B0QY90 Q9Y262
PDB IDs		3J8B 3J8C 6FEC 6YBD 6ZMW 6ZON 6ZP4 6ZVJ 7A09 7QP6 7QP7 8OZ0 8PJ1 8PJ2 8PJ3 8PJ4 8PJ5 8PJ6 8PPL 8RG0 8XXN 9BLN
Enriched GO Terms of Interacting Partners?		Eukaryotic Translation Initiation Factor 3 Complex Eukaryotic 48S Preinitiation Complex Formation Of Cytoplasmic Translation Initiation Complex Eukaryotic 43S Preinitiation Complex Macromolecule Biosynthetic Process Cytoplasmic Translational Initiation Translation Initiation Factor Activity Nucleolus Organization Translational Initiation RNA Polymerase Binding Protein-containing Complex Assembly Regulation Of Long-term Neuronal Synaptic Plasticity Protein-containing Complex Organization Regulation Of Gene Expression RNA Metabolic Process Nucleobase-containing Compound Biosynthetic Process Intrinsic Apoptotic Signaling Pathway Regulation Of Macromolecule Biosynthetic Process Synaptic Vesicle Transport Nucleolus Fibroblast Proliferation Protein-RNA Complex Assembly Beta-tubulin Binding Tau Protein Binding Response To Gamma Radiation Phosphatase Binding Regulation Of Adenylate Cyclase-inhibiting Adrenergic Receptor Signaling Pathway Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Neuronal Synaptic Plasticity Negative Regulation Of Gene Expression Negative Regulation Of Membrane Tubulation Receptor Internalization Vesicle Scission Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein GTPase Complex Eukaryotic Translation Initiation Factor 3 Complex, EIF3e Homomeric SMAD Protein Complex Negative Regulation Of Glycine Import Across Plasma Membrane Regulation Of Norepinephrine Uptake Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Hydrogen Peroxide Catabolic Process Transcription Termination Site Sequence-specific DNA Binding Nucleologenesis
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