TLR8

Description		toll like receptor 8
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GO Annotations	Cellular Component	Golgi Membrane Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane External Side Of Plasma Membrane Endosome Membrane Membrane Endolysosome Membrane
	Molecular Function	DNA Binding RNA Binding Double-stranded RNA Binding Single-stranded RNA Binding Protein Binding Signaling Receptor Activity Pattern Recognition Receptor Activity Identical Protein Binding
	Biological Process	Toll-like Receptor Signaling Pathway Immune System Process Inflammatory Response Immune Response Signal Transduction Canonical NF-kappaB Signal Transduction Response To Virus Immunoglobulin Mediated Immune Response Negative Regulation Of Interleukin-12 Production Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-beta Production Positive Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Toll-like Receptor 8 Signaling Pathway Positive Regulation Of Canonical NF-kappaB Signal Transduction Innate Immune Response Positive Regulation Of Innate Immune Response Defense Response To Virus Cellular Response To Mechanical Stimulus Defense Response To Other Organism Endolysosomal Toll-like Receptor Signaling Pathway
Pathways		Trafficking and processing of endosomal TLR Toll Like Receptor 7/8 (TLR7/8) Cascade SARS-CoV-2 activates/modulates innate and adaptive immune responses
Drugs		Imiquimod Resiquimod Selgantolimod Afimetoran
Diseases
GWAS		Celiac disease ( 20190752)
Novel Interacting Genes		4 novel interacting genes: BTK MYD88 RNF10 UTP18
Interacting Genes		4 interacting genes: BTK MYD88 RNF10 UTP18
Entrez ID		51311
HPRD ID		02296
Ensembl ID		ENSG00000101916
Uniprot IDs		A0AA49X8T4 Q9NR97
PDB IDs		3W3G 3W3J 3W3K 3W3L 3W3M 3W3N 3WN4 4QBZ 4QC0 4R07 4R08 4R09 4R0A 4R6A 5AWA 5AWB 5AWC 5AWD 5AZ5 5HDH 5WYX 5WYZ 5Z14 5Z15 6KYA 6TY5 6V9U 6WML 6ZJZ 7CRF 7R52 7R53 7R54 7RC9 7YTX 8PFI 9MHW 9MHX 9MHY
Enriched GO Terms of Interacting Partners?		Response To Molecule Of Fungal Origin MyD88-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Interleukin-17 Production Positive Regulation Of NLRP3 Inflammasome Complex Assembly Toll-like Receptor Signaling Pathway Regulation Of NLRP3 Inflammasome Complex Assembly Regulation Of B Cell Cytokine Production Monocyte Proliferation Positive Regulation Of Interleukin-17A Production Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of DNA-binding Transcription Factor Activity Cytoplasmic Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Type I Interferon Production Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production TIR Domain Binding Toll Binding ATP-dependent Histone Chaperone Activity Induced Systemic Resistance Regulation Of Cytokine Production Involved In Immune Response Regulation Of Type I Interferon Production Positive Regulation Of Type I Hypersensitivity Positive Regulation Of Lymphocyte Proliferation Regulation Of Interleukin-6 Production Positive Regulation Of Mononuclear Cell Proliferation B Cell Affinity Maturation Toll-like Receptor 5 Signaling Pathway Regulation Of DNA-binding Transcription Factor Activity Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signaling Pathway Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Leukocyte Proliferation Eosinophil Homeostasis Positive Regulation Of Type III Hypersensitivity Toll-like Receptor 8 Signaling Pathway Regulation Of Production Of Molecular Mediator Of Immune Response Positive Regulation Of Protein-containing Complex Assembly Positive Regulation Of Synoviocyte Proliferation Cellular Response To Molecule Of Fungal Origin Activation Of Innate Immune Response Toll-like Receptor TLR6:TLR2 Signaling Pathway Positive Regulation Of Canonical NF-kappaB Signal Transduction Intracellular Receptor Signaling Pathway Histamine Secretion By Mast Cell Postsynapse To Nucleus Signaling Pathway Extrinsic Component Of Postsynaptic Density Membrane Pwp2p-containing Subcomplex Of 90S Preribosome Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Mononuclear Cell Proliferation
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