RASL12

Description		RAS like family 12
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GO Annotations	Cellular Component	Plasma Membrane
	Molecular Function	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding
	Biological Process
Pathways
Drugs
Diseases
GWAS		White matter hyperintensity volume ( 33293549) White matter hyperintensity volume (adjusted for hypertension) ( 33293549) White matter hyperintensity volume x hypertension interaction (2df) ( 33293549)
Novel Interacting Genes		11 novel interacting genes: ACVR1 APP BMPR1B CLK1 FHL3 SMAD1 SMAD2 SMAD3 SMAD4 SMURF2 TGFBR1
Interacting Genes		11 interacting genes: ACVR1 APP BMPR1B CLK1 FHL3 SMAD1 SMAD2 SMAD3 SMAD4 SMURF2 TGFBR1
Entrez ID		51285
HPRD ID		15217
Ensembl ID		ENSG00000103710
Uniprot IDs		Q9NYN1
PDB IDs		3C5C
Enriched GO Terms of Interacting Partners?		SMAD Binding I-SMAD Binding Response To Growth Factor SMAD Protein Complex Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Activin Receptor Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Heteromeric SMAD Protein Complex Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus Positive Regulation Of Epithelial To Mesenchymal Transition Pattern Specification Process SMAD Protein Signal Transduction Transforming Growth Factor Beta Receptor Activity, Type I Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Developmental Process Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Cell Differentiation Regionalization Trophoblast Cell Migration Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Osteoblast Differentiation Ameboidal-type Cell Migration Positive Regulation Of SMAD Protein Signal Transduction Gastrulation Positive Regulation Of Extracellular Matrix Assembly Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Multicellular Organismal Process Transmembrane Receptor Protein Serine/threonine Kinase Activity Co-SMAD Binding Embryonic Pattern Specification Cell Fate Commitment Primary MiRNA Processing Regulation Of SMAD Protein Signal Transduction Response To Transforming Growth Factor Beta Regulation Of Cartilage Development Regulation Of MiRNA Transcription Cell Surface Receptor Signaling Pathway BMP Signaling Pathway Regulation Of MiRNA Metabolic Process In Utero Embryonic Development Animal Organ Development Chordate Embryonic Development Regulation Of Extracellular Matrix Assembly Anatomical Structure Morphogenesis Embryo Development Ending In Birth Or Egg Hatching Homomeric SMAD Protein Complex Multicellular Organism Development Regulation Of Cell Differentiation R-SMAD Binding
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