TLR7

Description		toll like receptor 7
Image
GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Lysosome Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Endosome Membrane Membrane Cytoplasmic Vesicle Early Phagosome Endolysosome Membrane Receptor Complex Phagocytic Vesicle
	Molecular Function	Double-stranded RNA Binding Single-stranded RNA Binding Protein Binding SiRNA Binding Pattern Recognition Receptor Activity
	Biological Process	MAPK Cascade Toll-like Receptor Signaling Pathway Immune System Process Inflammatory Response Immune Response Signal Transduction Canonical NF-kappaB Signal Transduction JNK Cascade Positive Regulation Of Chemokine Production Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-beta Production Positive Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Toll-like Receptor 7 Signaling Pathway Toll-like Receptor 8 Signaling Pathway Positive Regulation Of Canonical NF-kappaB Signal Transduction Innate Immune Response Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Inflammatory Response Defense Response To Virus Positive Regulation Of Macrophage Cytokine Production Response To CGMP Cellular Response To Mechanical Stimulus Defense Response To Other Organism Cellular Response To Virus Endolysosomal Toll-like Receptor Signaling Pathway
Pathways		Trafficking and processing of endosomal TLR Toll Like Receptor 7/8 (TLR7/8) Cascade Regulation of TLR by endogenous ligand Potential therapeutics for SARS SARS-CoV-1 activates/modulates innate immune responses SARS-CoV-2 activates/modulates innate and adaptive immune responses TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88 dependent cascade initiated on endosome Defective regulation of TLR7 by endogenous ligand RSV-host interactions
Drugs		Imiquimod Hydroxychloroquine Isatoribine ANA971 Golotimod RG-7795 Resiquimod Afimetoran
Diseases
GWAS		Celiac disease ( 20190752)
Novel Interacting Genes		3 novel interacting genes: GRAMD1A MYD88 RNF10
Interacting Genes		3 interacting genes: GRAMD1A MYD88 RNF10
Entrez ID		51284
HPRD ID		02295
Ensembl ID		ENSG00000196664
Uniprot IDs		B2R9N9 Q9NYK1
PDB IDs		7CYN
Enriched GO Terms of Interacting Partners?		TIR Domain Binding Toll Binding ATP-dependent Histone Chaperone Activity Induced Systemic Resistance Toll Signaling Pathway Neutrophil-mediated Killing Of Bacterium Regulation Of Interleukin-23 Production Response To Peptidoglycan Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Regulation Of Chemokine (C-X-C Motif) Ligand 1 Production Toll-like Receptor Binding Interleukin-33-mediated Signaling Pathway Response To Alcohol Cellular Response To Lipid Toll-like Receptor 8 Signaling Pathway Positive Regulation Of Interleukin-23 Production Response To Molecule Of Fungal Origin Interleukin-1 Receptor Binding Neutrophil Activation Involved In Immune Response Extrinsic Component Of Plasma Membrane Microglia Differentiation Ribosome-associated Ubiquitin-dependent Protein Catabolic Process Postsynapse To Nucleus Signaling Pathway Negative Regulation Of Schwann Cell Proliferation Extrinsic Component Of Postsynaptic Density Membrane Organelle Membrane Contact Site Endoplasmic Reticulum-plasma Membrane Contact Site Cellular Response To Oxidised Low-density Lipoprotein Particle Stimulus Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane MyD88-dependent Toll-like Receptor Signaling Pathway Establishment Of Endothelial Intestinal Barrier Cellular Response To Cholesterol Death Receptor Binding Negative Regulation Of Glial Cell Proliferation Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production Positive Regulation Of Myelination 3'-UTR-mediated MRNA Stabilization Cellular Response To Sterol Neutrophil Mediated Immunity Cellular Response To Lipoprotein Particle Stimulus Regulation Of Toll-like Receptor 4 Signaling Pathway Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Macrophage Cytokine Production Positive Regulation Of NLRP3 Inflammasome Complex Assembly Interleukin-1-mediated Signaling Pathway Regulation Of Macrophage Cytokine Production Response To Protozoan Establishment Of Endothelial Barrier Killing By Host Of Symbiont Cells
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