VRK3

Description		VRK serine/threonine kinase 3
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Transferase Activity Protein Phosphatase Binding Protein Phosphatase Activator Activity
	Biological Process	DNA Damage Response Signal Transduction Skeletal Muscle Tissue Development Negative Regulation Of ERK1 And ERK2 Cascade
Pathways		ERKs are inactivated
Drugs
Diseases
GWAS		Alzheimer's disease ( 33074286)
Novel Interacting Genes		5 novel interacting genes: CSNK2B FBXO7 OGT PLK1 RAN
Interacting Genes		5 interacting genes: CSNK2B FBXO7 OGT PLK1 RAN
Entrez ID		51231
HPRD ID		18289
Ensembl ID		ENSG00000105053
Uniprot IDs		Q8IV63
PDB IDs		2JII
Enriched GO Terms of Interacting Partners?		Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Mitotic Sister Chromatid Segregation Sister Chromatid Segregation Regulation Of Protein Catabolic Process Regulation Of Proteolysis Nuclear Chromosome Segregation Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Autophagy Of Mitochondrion Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Mitotic Spindle Organization Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Positive Regulation Of Protein Localization To Nucleus Protein Modification Process Negative Regulation Of Protein Catabolic Process Protein Localization To Organelle Synaptonemal Complex Disassembly Golgi Inheritance Microtubule Cytoskeleton Organization Involved In Mitosis RNA Nuclear Export Complex SnRNA Import Into Nucleus Pre-miRNA Export From Nucleus Nucleoplasm Chromosome Segregation Mitotic Cell Cycle Negative Regulation Of Proteolysis Viral Process Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Spindle Organization Regulation Of Protein Localization To Cell Periphery Centriole Regulation Of Protein Localization To Nucleus Protein-containing Complex Protein O-acetylglucosaminyltransferase Activity Lewy Body Core Negative Regulation Of Mitotic Cell Cycle Phase Transition Protein Localization To Nucleus Midbody RNA Import Into Nucleus Protein Domain Specific Binding Positive Regulation Of Activin Receptor Signaling Pathway
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