PCSK1

Description		proprotein convertase subtilisin/kexin type 1
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space Membrane Transport Vesicle Secretory Granule Cytoplasmic Vesicle Secretory Granule Lumen Neuron Projection
	Molecular Function	Endopeptidase Activity Serine-type Endopeptidase Activity Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Identical Protein Binding
	Biological Process	Proteolysis Cell-cell Signaling Protein Processing Peptide Hormone Processing Insulin Processing Peptide Biosynthetic Process
Pathways		Peptide hormone biosynthesis Insulin processing Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) Synthesis, secretion, and deacylation of Ghrelin
Drugs
Diseases
GWAS		Adult body size ( 32376654) Blood protein levels ( 30072576) BMI at adiposity peak ( 31840077) Body mass index ( 22344219 29273807 28892062 25673413 24861553) Body mass index and fasting glucose (pairwise) ( 33619380) Fasting blood glucose ( 22581228) Fasting blood glucose (BMI interaction) ( 22581228) Fasting blood glucose adjusted for BMI ( 25625282) Fasting blood proinsulin levels ( 23263489) Fasting glucose ( 34059833) Glycemic traits (pregnancy) ( 23903356) Insulin-related traits (multivariate analysis) ( 32002517) Menarche (age at onset) ( 25231870) Proinsulin levels ( 21873549) Type 2 diabetes ( 32499647) Waist circumference ( 23966867)
Novel Interacting Genes		5 novel interacting genes: FER IAPP PCSK1N PMCH REN
Interacting Genes		5 interacting genes: FER IAPP PCSK1N PMCH REN
Entrez ID		5122
HPRD ID		01201
Ensembl ID		ENSG00000175426
Uniprot IDs		P29120
PDB IDs
Enriched GO Terms of Interacting Partners?		Feeding Behavior G Protein-coupled Receptor Signaling Pathway Peptide Hormone Processing Signaling Receptor Ligand Precursor Processing Signaling Receptor Binding Male Gonad Development Adherens Junction Disassembly Hormone Activity Neuropeptide Signaling Pathway Type 1 Melanin-concentrating Hormone Receptor Binding Melanin-concentrating Hormone Activity Signaling Cell Communication Cell-cell Junction Disassembly Negative Regulation Of Synaptic Transmission, Dopaminergic Gonad Development Cellular Response To Macrophage Colony-stimulating Factor Stimulus Signal Transduction Negative Regulation Of Mast Cell Activation Involved In Immune Response Developmental Process Involved In Reproduction Tyrosine Phosphorylation Of STAT Protein Extracellular Matrix-cell Signaling Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Kit Signaling Pathway Reproductive Structure Development Amylin Receptor 1 Signaling Pathway Amylin Receptor 3 Signaling Pathway Extracellular Region Amylin Receptor 2 Signaling Pathway Hormone Metabolic Process Juxtaglomerular Apparatus Development Maintenance Of Blood Vessel Diameter Homeostasis By Renin-angiotensin Protein Processing Renin-angiotensin Regulation Of Aldosterone Production Amylin Receptor Signaling Pathway Regulation Of Blood Volume By Renin-angiotensin Diapedesis Regulation Of Biological Quality Regulation Of Synaptic Transmission, Dopaminergic Negative Regulation Of Mast Cell Activation Response To Macrophage Colony-stimulating Factor Response To CGMP Calcitonin Family Receptor Signaling Pathway Drinking Behavior Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Response To Lipopolysaccharide Protein Maturation Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Response To Molecule Of Bacterial Origin Cellular Developmental Process
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