SAR1B

Description		secretion associated Ras related GTPase 1B
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GO Annotations	Cellular Component	Cytoplasm Lysosome Lysosomal Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol ER To Golgi Transport Vesicle Membrane Membrane COPII Vesicle Coat Golgi Cisterna Membrane Endoplasmic Reticulum Exit Site
	Molecular Function	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity Metal Ion Binding Amino Acid Sensor Activity
	Biological Process	Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Regulation Of COPII Vesicle Coating Intracellular Protein Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Protein Transport Vesicle Organization Vesicle-mediated Transport Regulation Of Lipid Transport Lipoprotein Transport COPII Vesicle Coating Lipid Homeostasis Membrane Organization COPII-coated Vesicle Cargo Loading Lipid Export From Cell Regulation Of TORC1 Signaling Negative Regulation Of TORC1 Signaling Cellular Response To Leucine Starvation
Pathways		Regulation of cholesterol biosynthesis by SREBP (SREBF) COPII-mediated vesicle transport MHC class II antigen presentation Cargo concentration in the ER Chylomicron assembly SARS-CoV-2 activates/modulates innate and adaptive immune responses Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Drugs		Guanosine-5'-Diphosphate
Diseases		Chylomicron retention disease (CRD); Anderson disease
GWAS		Bipolar disorder ( 31043756) Hip circumference adjusted for BMI ( 34021172)
Novel Interacting Genes		4 novel interacting genes: CIDEB CREB3 JADE2 TMEM14B
Interacting Genes		4 interacting genes: CIDEB CREB3 JADE2 TMEM14B
Entrez ID		51128
HPRD ID		09647
Ensembl ID		ENSG00000152700
Uniprot IDs		Q9H029 Q9Y6B6
PDB IDs		8E0A 8E0B 8E0C 8E0D
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Deacetylase Activity Regulation Of Cell Growth Positive Regulation Of Monocyte Chemotaxis Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway CCR1 Chemokine Receptor Binding Induction Of Positive Chemotaxis Release From Viral Latency CAMP Response Element Binding Protein Binding Regulation Of Cell Cycle Positive Regulation Of Positive Chemotaxis Identical Protein Binding Histone H4K5 Acetyltransferase Activity Histone H3K14 Acetyltransferase Activity Histone H4K16 Acetyltransferase Activity Histone H4K8 Acetyltransferase Activity Histone Acetyltransferase Complex Histone H4K12 Acetyltransferase Activity Execution Phase Of Apoptosis COPI-coated Vesicle Phosphatidic Acid Binding COPII Vesicle Coat Lipid Transfer Activity Lipid Droplet Fusion Protein-lipid Complex Assembly COPII-coated Vesicle Cargo Loading Plasma Lipoprotein Particle Assembly Very-low-density Lipoprotein Particle Assembly Tetrapyrrole Biosynthetic Process Porphyrin-containing Compound Biosynthetic Process Heme Biosynthetic Process
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