PCK1

Description		phosphoenolpyruvate carboxykinase 1
Image
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Endoplasmic Reticulum Cytosol Extracellular Exosome
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Phosphoenolpyruvate Carboxykinase Activity Phosphoenolpyruvate Carboxykinase (GTP) Activity GTP Binding Kinase Activity Transferase Activity Lyase Activity Carboxy-lyase Activity Purine Nucleotide Binding Manganese Ion Binding Carboxylic Acid Binding Metal Ion Binding Protein Serine Kinase Activity (using GTP As Donor)
	Biological Process	Glucose Metabolic Process Gluconeogenesis Oxaloacetate Metabolic Process NLS-bearing Protein Import Into Nucleus Lipid Metabolic Process Response To Bacterium Peptidyl-serine Phosphorylation Propionate Catabolic Process Response To Insulin Cellular Response To Insulin Stimulus SREBP-SCAP Complex Retention In Endoplasmic Reticulum Glucose Homeostasis Response To Starvation Positive Regulation Of Memory T Cell Differentiation Dicarboxylic Acid Metabolic Process Positive Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Glyceraldehyde-3-phosphate Biosynthetic Process Glycerol Biosynthetic Process From Pyruvate Positive Regulation Of Lipid Biosynthetic Process Regulation Of Lipid Biosynthetic Process Cellular Response To Potassium Ion Starvation Protein Maturation Hepatocyte Differentiation Cellular Response To Glucose Stimulus Cellular Response To Dexamethasone Stimulus Tricarboxylic Acid Metabolic Process
Pathways		Abacavir metabolism Transcriptional regulation of white adipocyte differentiation Gluconeogenesis FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis
Drugs		Phosphoenolpyruvate 1-(2-Fluorobenzyl)-3-Butyl-8-(N-Acetyl-4-Aminobenzyl)-Xanthine 1-Allyl-3-Butyl-8-(N-Acetyl-4-Aminobenzyl)-Xanthine 5'-Guanylylmethylenebisphosphonate
Diseases
GWAS		Emphysema imaging phenotypes ( 26030696) Estimated glomerular filtration rate ( 31152163 31451708) Hematocrit ( 32888494) Hemoglobin ( 32888494) Prudent dietary pattern ( 28644415) Red blood cell count ( 32888494) Response to fenofibrate (adiponectin levels) ( 23149075) Serum alkaline phosphatase levels ( 31666285) Triglycerides ( 30275531) Type 2 diabetes ( 23300278)
Novel Interacting Genes		9 novel interacting genes: AKT1 APP C1R FBXO25 IKBKG INSIG1 INSIG2 RAE1 UBR5
Interacting Genes		9 interacting genes: AKT1 APP C1R FBXO25 IKBKG INSIG1 INSIG2 RAE1 UBR5
Entrez ID		5105
HPRD ID		02028
Ensembl ID		ENSG00000124253
Uniprot IDs		P35558
PDB IDs		1KHB 1KHE 1KHF 1KHG 1M51 1NHX 2GMV
Enriched GO Terms of Interacting Partners?		SREBP-SCAP Complex Retention In Endoplasmic Reticulum Negative Regulation Of SREBP Signaling Pathway Regulation Of SREBP Signaling Pathway Maintenance Of Protein Localization In Endoplasmic Reticulum Positive Regulation Of Cholesterol Biosynthetic Process NLS-bearing Protein Import Into Nucleus Positive Regulation Of Cholesterol Metabolic Process Regulation Of Cholesterol Biosynthetic Process ER-nucleus Signaling Pathway Positive Regulation Of Steroid Biosynthetic Process SREBP-SCAP-Insig Complex Positive Regulation Of Small Molecule Metabolic Process Negative Regulation Of Fatty Acid Metabolic Process Positive Regulation Of Steroid Metabolic Process Maintenance Of Protein Localization In Organelle Regulation Of Cholesterol Metabolic Process Maintenance Of Protein Location In Cell Regulation Of Cellular Response To Stress Maintenance Of Protein Location Nuclear Transport Nucleocytoplasmic Transport Maintenance Of Location In Cell Cranial Suture Morphogenesis Maintenance Of Location Regulation Of Steroid Biosynthetic Process SREBP Signaling Pathway Cellular Response To Sterol Depletion Regulation Of Response To Endoplasmic Reticulum Stress Protein Maturation Response To Sterol Depletion Anoikis Regulation Of Small Molecule Metabolic Process Cellular Response To Insulin Stimulus Protein K29-linked Ubiquitination Regulation Of Fatty Acid Metabolic Process Positive Regulation Of Lipid Biosynthetic Process Negative Regulation Of Lipid Metabolic Process Regulation Of Steroid Metabolic Process Negative Regulation Of Signal Transduction Negative Regulation Of Small Molecule Metabolic Process Oxysterol Binding Protein Import Into Nucleus Negative Regulation Of Signaling Negative Regulation Of Cell Communication Import Into Nucleus Establishment Of Localization In Cell Craniofacial Suture Morphogenesis Regulation Of Ketone Metabolic Process Positive Regulation Of Lipid Metabolic Process Negative Regulation Of Fatty Acid Biosynthetic Process
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