ACOX1

Description		acyl-CoA oxidase 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Peroxisome Peroxisomal Membrane Peroxisomal Matrix Cytosol Membrane
	Molecular Function	Acyl-CoA Oxidase Activity Fatty Acid Binding Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-CH Group Of Donors PDZ Domain Binding Protein Homodimerization Activity Flavin Adenine Dinucleotide Binding FAD Binding Long-chain Fatty Acyl-CoA Oxidase Activity
	Biological Process	Very Long-chain Fatty Acid Metabolic Process Generation Of Precursor Metabolites And Energy Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Beta-oxidation Unsaturated Fatty Acid Biosynthetic Process Prostaglandin Metabolic Process Spermatogenesis Fatty Acid Catabolic Process Peroxisome Fission Fatty Acid Oxidation Fatty Acid Beta-oxidation Using Acyl-CoA Oxidase Alpha-linolenic Acid Metabolic Process Cholesterol Homeostasis Long-chain Fatty Acid Biosynthetic Process Hydrogen Peroxide Biosynthetic Process Lipid Homeostasis Very Long-chain Fatty Acid Beta-oxidation Fatty Acid Derivative Biosynthetic Process
Pathways		Peroxisomal protein import Peroxisomal protein import TYSND1 cleaves peroxisomal proteins
Drugs		Flavin adenine dinucleotide (3R)-3-HYDROXYDODECANOIC ACID
Diseases		Peroxisomal beta-oxidation enzyme deficiency, including: Acyl-CoA oxidase (ACOX) deficiency; D-bifunctional protein (DBP) deficiency; Perrault syndrome; Sterol carrier protein X (SCPx) deficiency; 2-Methylacyl-CoA racemase (AMCR) deficiency; Hypercholanemia
GWAS		Body mass index ( 28552196) Diastolic blood pressure ( 27841878) Mean platelet volume ( 32888494) Pulse pressure ( 27841878) Systolic blood pressure ( 27841878 28135244) Urinary metabolite levels in chronic kidney disease ( 31959995) White matter hyperintensities ( 30002152) White matter hyperintensity burden ( 25663218)
Novel Interacting Genes		4 novel interacting genes: OGT SCP2 SLC2A4 TYSND1
Interacting Genes		4 interacting genes: OGT SCP2 SLC2A4 TYSND1
Entrez ID		51
HPRD ID		02030
Ensembl ID		ENSG00000161533
Uniprot IDs		Q15067
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Lipid Metabolic Process Peroxisomal Matrix Propionyl-CoA C2-trimethyltridecanoyltransferase Activity Propanoyl-CoA C-acyltransferase Activity Amylopectin Biosynthetic Process D-glucose Uniporter Activity Regulation Of Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Peroxisome Positive Regulation Of Lipid Metabolic Process Lipid Hydroperoxide Transport Oleic Acid Binding Acetyl-CoA C-myristoyltransferase Activity Positive Regulation Of Intracellular Cholesterol Transport Inositol Trisphosphate Biosynthetic Process Positive Regulation Of Brain-derived Neurotrophic Factor Receptor Signaling Pathway Response To Insulin Protein Processing Protein O-acetylglucosaminyltransferase Activity Regulation Of Lipid Biosynthetic Process Long-chain Fatty Acyl-CoA Binding Acetyl-CoA C-acyltransferase Activity Positive Regulation Of Intracellular Lipid Transport Carbohydrate Homeostasis Glucose Homeostasis White Fat Cell Proliferation Progesterone Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Insulin-responsive Compartment Glucose Import In Response To Insulin Stimulus Non-canonical Inflammasome Complex Assembly Positive Regulation Of Transcription By Glucose Phosphatidylcholine Transfer Activity Inositol Trisphosphate Metabolic Process Carbon Catabolite Regulation Of Transcription Regulation Of Intracellular Cholesterol Transport Dehydroascorbic Acid Transport Response To Peptide Hormone Fat Cell Proliferation Protein Maturation Regulation Of Intracellular Lipid Transport Regulation Of Transcription By Glucose Regulation Of Small Molecule Metabolic Process Lipid Binding D-glucose Transmembrane Transporter Activity C21-steroid Hormone Biosynthetic Process Phosphatidylinositol Transfer Activity NSL Complex
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