PCDH1

Description		protocadherin 1
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GO Annotations	Cellular Component	Nucleoplasm Nucleolus Plasma Membrane Cell-cell Junction Membrane Cell Junction Anchoring Junction
	Molecular Function	Calcium Ion Binding Cell Adhesion Molecule Binding
	Biological Process	Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Cell-cell Signaling Nervous System Development
Pathways
Drugs
Diseases
GWAS		Cerebral amyloid deposition (PET imaging) ( 26252872) Lung cancer ( 28604730) Major depressive disorder ( 23377640) Myopia (pathological) ( 23406873)
Novel Interacting Genes		3 novel interacting genes: ATF7IP SMAD3 VKORC1
Interacting Genes		3 interacting genes: ATF7IP SMAD3 VKORC1
Entrez ID		5097
HPRD ID		04692
Ensembl ID		ENSG00000156453
Uniprot IDs		A8K0E7 B4DUA8 B4E2D8 Q08174
PDB IDs		6BX7 6MGA 6PIM 6VFP
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Transforming Growth Factor Beta3 Production Negative Regulation Of Lung Blood Pressure Nuclear Mineralocorticoid Receptor Binding Peptidyl-glutamic Acid Carboxylation Oxidoreductase Activity, Acting On CH Or CH2 Groups, Disulfide As Acceptor Vitamin-K-epoxide Reductase (warfarin-insensitive) Activity Vitamin-K-epoxide Reductase (warfarin-sensitive) Activity Sterol Response Element Binding Paraxial Mesoderm Morphogenesis Transcription Regulator Complex Regulation Of Lung Blood Pressure Mesoderm Morphogenesis Immune System Development Transdifferentiation SMAD Protein Complex Pericardium Development DEAD/H-box RNA Helicase Binding Heteromeric SMAD Protein Complex Trophoblast Cell Migration Regulation Of Transforming Growth Factor Beta2 Production DNA-binding Transcription Repressor Activity Transforming Growth Factor Beta Receptor Binding Osteoblast Development Negative Regulation Of Osteoblast Proliferation Co-SMAD Binding Nuclear Glucocorticoid Receptor Binding Negative Regulation Of Cardiac Muscle Hypertrophy In Response To Stress I-SMAD Binding Nodal Signaling Pathway Negative Regulation Of Cytosolic Calcium Ion Concentration Lens Fiber Cell Differentiation Positive Regulation Of Extracellular Matrix Assembly Primary MiRNA Processing Embryonic Foregut Morphogenesis Quinone Binding Peptidyl-glutamic Acid Modification Vitamin K Metabolic Process Positive Regulation Of Transforming Growth Factor Beta Production Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Positive Regulation Of Chondrocyte Differentiation Regulation Of Osteoblast Proliferation Negative Regulation Of MiRNA Transcription Positive Regulation Of Positive Chemotaxis Embryonic Cranial Skeleton Morphogenesis Positive Regulation Of Extracellular Matrix Organization Regulation Of Extracellular Matrix Assembly Thyroid Gland Development SMAD Protein Signal Transduction BHLH Transcription Factor Binding Positive Regulation Of Focal Adhesion Assembly
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