IRX4

Description		iroquois homeobox 4
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Heart Development Neuron Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Cell Development Establishment Of Animal Organ Orientation
Pathways
Drugs
Diseases
GWAS		Body mass index (adult) ( 28430825) Cardiovascular disease risk factors ( 21779381) Dental caries (decayed and filled deciduous tooth surfaces) ( 31533690) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Erosive tooth wear (severe vs non-severe) ( 29898447) Erosive tooth wear (severe vs none or mild) ( 29898447) Lack of perseverance ( 30718321) Prostate cancer ( 26443449 31562322) Spatial processing ( 31596458)
Novel Interacting Genes		3 novel interacting genes: LINC00839 POU6F2 RARA
Interacting Genes		3 interacting genes: LINC00839 POU6F2 RARA
Entrez ID		50805
HPRD ID		09369
Ensembl ID		ENSG00000113430
Uniprot IDs		P78413
PDB IDs
Enriched GO Terms of Interacting Partners?		DNA-binding Transcription Repressor Activity Negative Regulation Of Granulocyte Differentiation Trachea Cartilage Development Sertoli Cell Fate Commitment Prostate Gland Development Retinoic Acid-responsive Element Binding Epithelial Cell Fate Commitment Ventricular Cardiac Muscle Cell Differentiation Chondroblast Differentiation Growth Plate Cartilage Development Glandular Epithelial Cell Development Positive Regulation Of T-helper 2 Cell Differentiation Alpha-actinin Binding Protein Kinase B Binding Positive Regulation Of Interleukin-5 Production Columnar/cuboidal Epithelial Cell Development MRNA Regulatory Element Binding Translation Repressor Activity Regulation Of Granulocyte Differentiation Response To Vitamin A Heterocyclic Compound Binding Positive Regulation Of Interleukin-13 Production Embryonic Camera-type Eye Development Nuclear Protein Quality Control By The Ubiquitin-proteasome System Cellular Response To Estrogen Stimulus Positive Regulation Of Interleukin-4 Production Cartilage Development Involved In Endochondral Bone Morphogenesis Positive Regulation Of Type 2 Immune Response Retinoic Acid Receptor Signaling Pathway Negative Regulation Of MiRNA Transcription Face Development DNA-binding Transcription Factor Activity Positive Regulation Of T-helper Cell Differentiation MRNA 5'-UTR Binding Protein Kinase A Binding Regulation Of Interleukin-5 Production Retinoic Acid Binding Apoptotic Cell Clearance Outflow Tract Septum Morphogenesis Cardiac Muscle Cell Differentiation Regulation Of Interleukin-4 Production Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins Regulation Of Type 2 Immune Response Negative Regulation Of Cartilage Development
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