PNPLA8

Description		patatin like domain 8, phospholipase A2
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Peroxisome Peroxisomal Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Mitochondrial Membrane
	Molecular Function	Phospholipase Activity Phosphatidylcholine Lysophospholipase Activity Phospholipase A2 Activity ATP Binding Phospholipase A1 Activity Hydrolase Activity Calcium-independent Phospholipase A2 Activity
	Biological Process	Prostaglandin Biosynthetic Process Lipid Metabolic Process Fatty Acid Metabolic Process Lipid Catabolic Process Arachidonate Metabolic Process Cardiolipin Metabolic Process Phosphatidylcholine Catabolic Process Intracellular Signal Transduction Linoleic Acid Metabolic Process Phosphatidylethanolamine Catabolic Process Arachidonate Secretion Lipid Homeostasis Triglyceride Homeostasis Regulation Of Cellular Response To Oxidative Stress
Pathways		Acyl chain remodelling of PC Acyl chain remodelling of PE
Drugs
Diseases
GWAS		JT interval (sulfonylurea treatment interaction) ( 27958378) Post bronchodilator FEV1/FVC ratio ( 26634245) Smoking behavior ( 22006218) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Novel Interacting Genes		1 novel interacting genes: FLT4
Interacting Genes		1 interacting genes: FLT4
Entrez ID		50640
HPRD ID		13741
Ensembl ID		ENSG00000135241
Uniprot IDs		Q9NP80
PDB IDs
Enriched GO Terms of Interacting Partners?		Respiratory Gaseous Exchange By Respiratory System Lymph Vessel Development Growth Factor Binding Positive Regulation Of Vascular Endothelial Growth Factor Production Sprouting Angiogenesis Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Vascular Endothelial Growth Factor Production Transmembrane Receptor Protein Tyrosine Kinase Activity Vascular Endothelial Growth Factor Receptor Activity Lymphangiogenesis Cellular Response To Vascular Endothelial Growth Factor Stimulus Peptidyl-tyrosine Phosphorylation Respiratory System Process Vascular Endothelial Growth Factor Signaling Pathway Lung Alveolus Development Regulation Of Blood Vessel Remodeling Vasculature Development Regulation Of Tissue Remodeling Blood Vessel Morphogenesis Protein Phosphatase Binding Positive Regulation Of Endothelial Cell Proliferation Positive Regulation Of JNK Cascade Protein Autophosphorylation Positive Regulation Of Endothelial Cell Migration Protein Tyrosine Kinase Activity Regulation Of JNK Cascade Regulation Of Endothelial Cell Proliferation
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