ATP6V0A4

Description		ATPase H+ transporting V0 subunit a4
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GO Annotations	Cellular Component	Vacuolar Proton-transporting V-type ATPase, V0 Domain Lysosomal Membrane Endosome Plasma Membrane Brush Border Endosome Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane Vacuolar Proton-transporting V-type ATPase Complex Phagocytic Vesicle Membrane Synaptic Vesicle Membrane Brush Border Membrane Proton-transporting V-type ATPase Complex Proton-transporting V-type ATPase, V0 Domain Apical Part Of Cell Extracellular Exosome
	Molecular Function	Protein Binding Proton-transporting ATPase Activity, Rotational Mechanism ATPase Binding
	Biological Process	Ossification Monoatomic Ion Transport Regulation Of PH Vacuolar Acidification Sensory Perception Of Sound Intracellular PH Reduction Renal Tubular Secretion Synaptic Vesicle Lumen Acidification Proton Transmembrane Transport
Pathways		ROS and RNS production in phagocytes Insulin receptor recycling Transferrin endocytosis and recycling Ion channel transport
Drugs		Tiludronic acid
Diseases		Distal renal tubular acidosis (RTA type 1)
GWAS		Age-related hearing impairment ( 34108613) F-cell distribution in sickle cell anaemia ( 21326311) HDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535)
Novel Interacting Genes		2 novel interacting genes: CYTH2 PFKM
Interacting Genes		2 interacting genes: CYTH2 PFKM
Entrez ID		50617
HPRD ID		05576
Ensembl ID		ENSG00000105929
Uniprot IDs		Q9HBG4
PDB IDs		7UNF
Enriched GO Terms of Interacting Partners?		Phosphofructokinase Activity Glycolysis From Storage Polysaccharide Through Glucose-1-phosphate 6-phosphofructokinase Activity 6-phosphofructokinase Complex Fructose-6-phosphate Binding Fructose Binding Fructose 1,6-bisphosphate Metabolic Process Glycolytic Process Through Glucose-6-phosphate Glycogen Catabolic Process Carbohydrate Phosphorylation Fructose 6-phosphate Metabolic Process Glycolytic Process Through Fructose-6-phosphate Canonical Glycolysis Regulation Of ARF Protein Signal Transduction Inositol 1,4,5 Trisphosphate Binding Muscle Cell Cellular Homeostasis Polysaccharide Catabolic Process Sperm Principal Piece Glucose Catabolic Process ADP Catabolic Process ADP Metabolic Process Purine Ribonucleoside Diphosphate Catabolic Process Nucleoside Diphosphate Catabolic Process Glycolytic Process Ribonucleoside Diphosphate Catabolic Process Glycogen Metabolic Process Pyruvate Metabolic Process Energy Reserve Metabolic Process Polysaccharide Metabolic Process Purine Ribonucleotide Catabolic Process Ribonucleoside Diphosphate Metabolic Process Purine Nucleotide Catabolic Process Positive Regulation Of Insulin Secretion Nucleoside Diphosphate Metabolic Process Kinase Binding Nicotinamide Nucleotide Metabolic Process Nucleotide Catabolic Process Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Peptide Secretion Carbohydrate Catabolic Process
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