P2RY1

Description		purinergic receptor P2Y1
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GO Annotations	Cellular Component	Plasma Membrane Cilium Cell Surface Postsynaptic Density Membrane Basolateral Plasma Membrane Apical Plasma Membrane Dendrite Cell Body Postsynaptic Membrane Presynaptic Active Zone Membrane Glutamatergic Synapse
	Molecular Function	Nucleotide Binding G Protein-coupled ADP Receptor Activity G Protein-coupled Receptor Activity Protein Binding ATP Binding Signaling Receptor Regulator Activity A1 Adenosine Receptor Binding Signaling Receptor Activity ADP Binding G Protein-coupled Purinergic Nucleotide Receptor Activity G Protein-coupled ATP Receptor Activity Protein Heterodimerization Activity Scaffold Protein Binding
	Biological Process	G Protein-coupled Adenosine Receptor Signaling Pathway Monoatomic Ion Transport Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Blood Coagulation Hemostasis Glial Cell Migration Regulation Of Cell Shape Response To Mechanical Stimulus Negative Regulation Of Norepinephrine Secretion Signal Transduction Involved In Regulation Of Gene Expression Platelet Activation Positive Regulation Of Inositol Trisphosphate Biosynthetic Process G Protein-coupled Purinergic Nucleotide Receptor Signaling Pathway Eating Behavior Positive Regulation Of Monoatomic Ion Transport Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Hormone Secretion Establishment Of Localization In Cell Positive Regulation Of Penile Erection Positive Regulation Of ERK1 And ERK2 Cascade Response To Growth Factor Cellular Response To ATP Cellular Response To Purine-containing Compound Protein Localization To Plasma Membrane Relaxation Of Muscle Blood Vessel Diameter Maintenance Regulation Of Presynaptic Cytosolic Calcium Ion Concentration Regulation Of Synaptic Vesicle Exocytosis
Pathways		G alpha (q) signalling events P2Y receptors ADP signalling through P2Y purinoceptor 1 ADP signalling through P2Y purinoceptor 1
Drugs		Promethazine
Diseases
GWAS		Body mass index (change over time) in gastrointestinal cancer or chronic obstructive pulmonary disease ( 28044437) Chronotype ( 30696823) Immune reponse to smallpox (secreted IL-2) ( 22610502) Metabolite levels ( 23823483) Serum sulfate level ( 27412988)
Novel Interacting Genes		4 novel interacting genes: ADORA1 JAK1 NHERF1 NHERF2
Interacting Genes		4 interacting genes: ADORA1 JAK1 NHERF1 NHERF2
Entrez ID		5028
HPRD ID		03103
Ensembl ID		ENSG00000169860
Uniprot IDs		P47900
PDB IDs		4XNV 4XNW 7XXH 8WJX
Enriched GO Terms of Interacting Partners?		Type 2 Metabotropic Glutamate Receptor Binding Type 3 Metabotropic Glutamate Receptor Binding Endomembrane System Protein-membrane Adaptor Activity Phosphatase Binding Localization Within Membrane Positive Regulation Of Nucleoside Transport Negative Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Beta-catenin Binding Renal Phosphate Ion Absorption Renal System Process Negative Regulation Of Mucus Secretion Purine Nucleoside Binding Negative Regulation Of Neurotrophin Production Regulation Of Renal Phosphate Excretion Dopamine Receptor Binding Regulation Of Presynaptic Cytosolic Calcium Ion Concentration Regulation Of Respiratory Gaseous Exchange By Nervous System Process Negative Regulation Of Synaptic Transmission, Glutamatergic Negative Regulation Of Amino Acid Transport G Protein-coupled Purinergic Nucleotide Receptor Signaling Pathway Regulation Of Respiratory System Process Regulation Of Mucus Secretion Heterotrimeric G-protein Binding Regulation Of Long-term Synaptic Depression Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Cellular Localization Negative Regulation Of Long-term Synaptic Potentiation Negative Regulation Of Acute Inflammatory Response Vascular Process In Circulatory System Negative Regulation Of Circadian Sleep/wake Cycle, Sleep Negative Regulation Of Cell Motility Negative Regulation Of Locomotion G Protein-coupled Adenosine Receptor Activity Negative Regulation Of Cell Migration Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Asymmetric Synapse Negative Regulation Of Long-term Synaptic Depression Regulation Of Glomerular Filtration Mucus Secretion Axolemma Regulation Of Metal Ion Transport Circulatory System Process Inorganic Ion Homeostasis Positive Regulation Of Dephosphorylation Negative Regulation Of Glutamate Secretion Regulation Of Monoatomic Ion Transport Negative Regulation Of Synaptic Transmission, GABAergic Negative Regulation Of Circadian Rhythm G Protein-coupled Adenosine Receptor Signaling Pathway
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