NTHL1

Description		nth like DNA glycosylase 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Mitochondrion
	Molecular Function	Oxidized Pyrimidine Nucleobase Lesion DNA N-glycosylase Activity DNA Binding Damaged DNA Binding Double-stranded DNA Binding Catalytic Activity DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity Endonuclease Activity Protein Binding Oxidized Purine Nucleobase Lesion DNA N-glycosylase Activity Hydrolase Activity Hydrolase Activity, Acting On Glycosyl Bonds Lyase Activity DNA N-glycosylase Activity Metal Ion Binding Iron-sulfur Cluster Binding 4 Iron, 4 Sulfur Cluster Binding Class I DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity
	Biological Process	DNA Repair Base-excision Repair Base-excision Repair, AP Site Formation Nucleotide-excision Repair DNA Damage Response Depyrimidination
Pathways		Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Displacement of DNA glycosylase by APEX1 Defective NTHL1 substrate processing Defective NTHL1 substrate binding
Drugs
Diseases
GWAS		Adult body size ( 32376654) Longevity ( 20834067)
Novel Interacting Genes		6 novel interacting genes: ERCC5 PCNA PKD1 RBX1 SRPK2 TP53
Interacting Genes		6 interacting genes: ERCC5 PCNA PKD1 RBX1 SRPK2 TP53
Entrez ID		4913
HPRD ID		04039
Ensembl ID		ENSG00000065057
Uniprot IDs		E5KTI5 P78549
PDB IDs		7RDS 7RDT
Enriched GO Terms of Interacting Partners?		Response To UV Nucleotide-excision Repair Response To Light Stimulus Cellular Response To UV Response To Radiation Transcription-coupled Nucleotide-excision Repair Cellular Response To Light Stimulus Negative Regulation Of Mitophagy Response To UV-C Base-excision Repair, AP Site Formation DNA Repair Cellular Response To Radiation Response To Stress Replication Fork DNA Metabolic Process 14-3-3 Protein Binding DNA Damage Response Negative Regulation Of Macroautophagy Heart Development Nucleic Acid Metabolic Process Regulation Of Mitophagy DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Autophagy Of Mitochondrion Protein-containing Complex Binding Mitophagy Response To Oxidative Stress Receptor Tyrosine Kinase Binding Regulation Of Cell Cycle Cellular Response To Xenobiotic Stimulus Regulation Of Proteolysis Damaged DNA Binding Positive Regulation Of Neuron Apoptotic Process Interferon-mediated Signaling Pathway Autophagy Of Mitochondrion PCNA Complex Replisome Metanephric Distal Tubule Morphogenesis Negative Regulation Of Helicase Activity Negative Regulation Of G1 To G0 Transition Nucleobase-containing Compound Metabolic Process Regulation Of DNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Protein Tetramerization Positive Regulation Of Biosynthetic Process Regulation Of Mitotic Cell Cycle Signal Transduction By P53 Class Mediator Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Response To Amino Acid PCNA-p21 Complex
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