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NEU1
Description
neuraminidase 1
Image
No pdb structure
GO Annotations
Cellular Component
Extracellular Region
Cytoplasm
Lysosome
Lysosomal Membrane
Plasma Membrane
Membrane
Cell Junction
Cytoplasmic Vesicle
Specific Granule Lumen
Lysosomal Lumen
Extracellular Exosome
Molecular Function
Exo-alpha-sialidase Activity
Protein Binding
Hydrolase Activity
Hydrolase Activity, Acting On Glycosyl Bonds
Alpha-sialidase Activity
Biological Process
Lipid Metabolic Process
Ganglioside Catabolic Process
Oligosaccharide Catabolic Process
Lipid Catabolic Process
Pathways
Sialic acid metabolism
Defective NEU1 causes sialidosis
Neutrophil degranulation
Glycosphingolipid catabolism
Drugs
Oseltamivir
Celecoxib
Acetylsalicylic acid
Diseases
Progressive myoclonic epilepsy (PME), including: Lafora disease (LBD); Unverricht-Lundborg disease (ULD); Neuronal ceroid lipofuscinoses (NCL); Type I sialidosis; Action myoclonus-renal failure syndrome (AMRF); Type III Gaucher disease (GD)
Sialidosis; Mucolipidosis I
Galactosialidosis
GWAS
A body shape index (
34021172
)
Asthma (
31619474
)
Asthma (childhood onset) (
31619474
)
Asthma and major depressive disorder (
31619474
)
Autism spectrum disorder or schizophrenia (
28540026
)
Basal cell carcinoma (
27539887
)
Estimated glomerular filtration rate (
31152163
)
Inflammatory bowel disease (
28067908
)
Neutrophil percentage of white cells (
32888494
)
Platelet distribution width (
32888494
)
Small cell lung carcinoma (
28604730
)
Squamous cell lung carcinoma (
28604730
)
Ulcerative colitis (
28067908
)
Waist-hip index (
34021172
)
Novel Interacting Genes
38 novel interacting genes:
AQP6
CCR9
CD79A
CDC42SE2
CERS3
CERS4
CREB3
CREB3L1
CTSA
EBP
EEF1A1
ERGIC3
ERRFI1
GLB1
GOLM1
GPR152
GPX8
HSD17B11
IGF1
JUNB
KCNA2
KCNA4
LIG4
LMNA
MAF
MGST3
MSH5
MUC1
NFYA
NOTCH4
PBX2
SLC10A1
SLC10A6
SLC17A2
SLC18A1
SLC39A9
TMEM14B
UBC
Interacting Genes
38 interacting genes:
AQP6
CCR9
CD79A
CDC42SE2
CERS3
CERS4
CREB3
CREB3L1
CTSA
EBP
EEF1A1
ERGIC3
ERRFI1
GLB1
GOLM1
GPR152
GPX8
HSD17B11
IGF1
JUNB
KCNA2
KCNA4
LIG4
LMNA
MAF
MGST3
MSH5
MUC1
NFYA
NOTCH4
PBX2
SLC10A1
SLC10A6
SLC17A2
SLC18A1
SLC39A9
TMEM14B
UBC
Entrez ID
4758
HPRD ID
09751
Ensembl ID
ENSG00000204386
Uniprot IDs
Q5JQI0
Q99519
PDB IDs
Enriched GO Terms of Interacting Partners
?
Membrane
Endoplasmic Reticulum Membrane
Bile Acid:sodium Symporter Activity
Integrated Stress Response Signaling
Sphingosine N-acyltransferase Activity
Regulation Of Chaperone-mediated Autophagy
Lung Vasculature Development
Negative Regulation Of Apoptotic Signaling Pathway
Vasculature Development
RNA Polymerase II Transcription Regulator Complex
Voltage-gated Monoatomic Ion Channel Activity Involved In Regulation Of Presynaptic Membrane Potential
Negative Regulation Of Cardiac Muscle Hypertrophy In Response To Stress
Regulation Of Type B Pancreatic Cell Proliferation
Endoplasmic Reticulum
Regulation Of Cardiac Muscle Hypertrophy
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