NDP

Description		norrin cystine knot growth factor NDP
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cell Surface Extracellular Matrix
	Molecular Function	Frizzled Binding Cytokine Activity Protein Binding Protein Homodimerization Activity
	Biological Process	Mitotic Cell Cycle Re-entry Into Mitotic Cell Cycle Action Potential Angiogenesis Response To Hypoxia Placenta Development Blood Vessel Remodeling Lens Development In Camera-type Eye Retinal Pigment Epithelium Development Neural Retina Development Tricarboxylic Acid Cycle Transcription By RNA Polymerase II Glycine Metabolic Process L-serine Metabolic Process Protein Targeting To Lysosome Glutathione Metabolic Process Inflammatory Response Vacuole Organization Transforming Growth Factor Beta Receptor Signaling Pathway Smoothened Signaling Pathway Nervous System Development Visual Perception Intracellular Protein Localization Cell Population Proliferation Gene Expression Retina Layer Formation Microglia Differentiation Wnt Signaling Pathway Dendrite Development Protein Ubiquitination Optic Nerve Development Neuron Differentiation Retinal Ganglion Cell Axon Guidance Extracellular Matrix-cell Signaling Exploration Behavior Endothelial Cell Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Decidualization Response To Axon Injury Neuron Apoptotic Process Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Retina Development In Camera-type Eye Retina Morphogenesis In Camera-type Eye Canonical Wnt Signaling Pathway Retinal Rod Cell Differentiation Establishment Of Blood-brain Barrier Dendritic Spine Development Retina Vasculature Development In Camera-type Eye Retina Vasculature Morphogenesis In Camera-type Eye Retinal Blood Vessel Morphogenesis Microglial Cell Proliferation Ubiquitin-dependent Endocytosis Cellular Response To Hypoxia Retina Blood Vessel Maintenance Norrin Signaling Pathway Cone Retinal Bipolar Cell Differentiation Establishment Of Blood-retinal Barrier
Pathways
Drugs
Diseases		Familial exudative vitreoretinopathy (FEVR), including: Exudative vitreoretinopathy 1 (EVR1); Exudative vitreoretinopathy2, X-linked (EVR2); Exudative vitreoretinopathy 4 (EVR4); Exudative vitreoretinopathy 5 (EVR5); Norrie disease (ND)
GWAS		Glaucoma (primary open-angle) ( 33627673) Heel bone mineral density ( 28869591 30598549) Mean arterial pressure ( 29403010)
Novel Interacting Genes		2 novel interacting genes: APP PPP1CA
Interacting Genes		2 interacting genes: APP PPP1CA
Entrez ID		4693
HPRD ID		02404
Ensembl ID		ENSG00000124479
Uniprot IDs		Q00604
PDB IDs		4MY2 5BPU 5BQ8 5BQB 5BQC 5BQE 5CL1 8WVX 8WVY
Enriched GO Terms of Interacting Partners?		Response To Lead Ion Transition Metal Ion Binding Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Carbohydrate Catabolic Process Amyloid-beta Complex Regulation Of Extrinsic Apoptotic Signaling Pathway Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Small Molecule Metabolic Process Perikaryon Dendritic Spine Regulation Of Generation Of Precursor Metabolites And Energy Acetylcholine Receptor Activator Activity PTB Domain Binding Regulation Of Canonical Wnt Signaling Pathway Presynapse Regulation Of Wnt Signaling Pathway Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Postsynapse Response To Metal Ion Response To Light Stimulus Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Regulation Of Small Molecule Metabolic Process Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization RNA Polymerase II CTD Heptapeptide Repeat S5 Phosphatase Activity Positive Regulation Of Termination Of RNA Polymerase II Transcription, Poly(A)-coupled Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Positive Regulation Of Termination Of DNA-templated Transcription Positive Regulation Of Termination Of RNA Polymerase II Transcription Regulation Of Translation Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Main Axon Regulation Of Apoptotic Signaling Pathway
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