MSH5

Description		mutS homolog 5
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus
	Molecular Function	Nucleotide Binding DNA Binding Double-stranded DNA Binding Protein Binding ATP Binding Mismatched DNA Binding ATP-dependent DNA Damage Sensor Activity
	Biological Process	DNA Repair Mismatch Repair DNA Damage Response Meiosis I Chiasma Assembly Meiotic Cell Cycle
Pathways		Meiotic recombination
Drugs
Diseases
GWAS		A body shape index ( 34021172) Asthma ( 31619474) Asthma (childhood onset) ( 31619474) Asthma and major depressive disorder ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Blond vs. brown/black hair color ( 30531825) Clozapine-induced agranulocytosis/granulocytopenia in treatment-resistant schizophrenia ( 26876947) Cutaneous lupus erythematosus ( 25827949) Hip circumference adjusted for BMI ( 34021172) Inflammatory bowel disease ( 28067908) Lung cancer ( 18978787) Mastocytosis ( 32752121) Medication use (anilides) ( 31015401) Menopause (age at onset) ( 26414677) Pulse pressure ( 27618448) Systemic lupus erythematosus ( 26316170) Systemic mastocytosis ( 32752121) Systolic blood pressure ( 27618448) Takayasu arteritis ( 25604533) Ulcerative colitis ( 28067908 24837172)
Novel Interacting Genes		6 novel interacting genes: MLH1 MLH3 MSH4 NEU1 NOTCH4 TRIM54
Interacting Genes		6 interacting genes: MLH1 MLH3 MSH4 NEU1 NOTCH4 TRIM54
Entrez ID		4439
HPRD ID		04544
Ensembl ID		ENSG00000204410
Uniprot IDs		A0A024RCM1 O43196
PDB IDs
Enriched GO Terms of Interacting Partners?		Mismatched DNA Binding ATP-dependent DNA Damage Sensor Activity Mismatch Repair Reciprocal Meiotic Recombination Chiasma Synaptonemal Complex Condensed Chromosome Homologous Recombination Condensed Nuclear Chromosome Chromosome Organization Involved In Meiotic Cell Cycle Mismatch Repair Complex Homologous Chromosome Pairing At Meiosis DNA Recombination Male Meiotic Nuclear Division Male Germ Cell Nucleus Chromosome Organization Female Gamete Generation Meiosis I Cell Cycle Process Meiotic Nuclear Division Late Recombination Nodule Meiotic Metaphase I Homologous Chromosome Alignment Recombination Nodule Nuclear Division Reproductive Process DNA Repair Meiotic Cell Cycle Meiotic Spindle Midzone Assembly Meiotic Metaphase Chromosome Alignment Alpha-sialidase Activity Male Meiosis Chromosome Segregation MutLalpha Complex DNA Metabolic Process Guanine/thymine Mispair Binding Negative Regulation Of Mitotic Recombination Exo-alpha-sialidase Activity Satellite DNA Binding DNA Damage Response Homologous Chromosome Segregation Female Meiosis Chromosome Segregation Luteolysis Positive Regulation Of Isotype Switching To IgA Isotypes Centromeric DNA Binding MutSalpha Complex Binding Regulation Of Mitotic Recombination Positive Regulation Of Transcription Of Notch Receptor Target Female Meiosis I Meiotic Telomere Clustering Chromosome Localization To Nuclear Envelope Involved In Homologous Chromosome Segregation Ganglioside Catabolic Process Telomere Localization
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