EIF2AK4

Description		eukaryotic translation initiation factor 2 alpha kinase 4
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Cytosolic Ribosome
	Molecular Function	TRNA Binding Nucleotide Binding RNA Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Eukaryotic Translation Initiation Factor 2alpha Kinase Activity ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity
	Biological Process	DNA Damage Checkpoint Signaling Positive Regulation Of Defense Response To Virus By Host Adaptive Immune Response T Cell Activation Involved In Immune Response Immune System Process Positive Regulation Of Adaptive Immune Response Translational Initiation Regulation Of Translation Regulation Of Translational Initiation Protein Phosphorylation Nervous System Development Learning Long-term Memory Regulation Of Translational Initiation By EIF2 Alpha Phosphorylation Viral Translation Negative Regulation Of Translational Initiation In Response To Stress Negative Regulation Of CREB Transcription Factor Activity Cellular Response To Amino Acid Starvation Cellular Response To UV Response To Endoplasmic Reticulum Stress Host-mediated Suppression Of Viral Genome Replication Negative Regulation Of Neuron Differentiation Negative Regulation Of Translational Initiation Protein Autophosphorylation Defense Response To Virus Regulation Of Cell Cycle Regulation Of Feeding Behavior Cellular Response To Cold Positive Regulation Of Translational Initiation In Response To Starvation GCN2-mediated Signaling Positive Regulation Of Long-term Synaptic Potentiation Neuron Projection Extension
Pathways		Response of EIF2AK4 (GCN2) to amino acid deficiency
Drugs		Fostamatinib
Diseases
GWAS		Alanine aminotransferase levels ( 34315874) Aspartate aminotransferase levels ( 34315874) Body mass index ( 24827717) Corneal curvature ( 22969067) Diastolic blood pressure ( 27841878) Ewing sarcoma ( 22327514) Femur bone mineral density x serum urate levels interaction ( 34046847) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular hemoglobin concentration ( 32888494) Mean corpuscular volume ( 32888494) Platelet distribution width ( 32888494) Pulse pressure ( 27841878) Red blood cell count ( 32888494) Red cell distribution width ( 27863252 28957414 32888494) Response to haloperidol in psychosis ( 24751813) Reticulocyte fraction of red cells ( 27863252) Systolic blood pressure ( 30578418 27841878)
Novel Interacting Genes		7 novel interacting genes: ARRB1 ARRB2 GGNBP1 RNF10 SMAD1 SMAD4 TGFBR1
Interacting Genes		7 interacting genes: ARRB1 ARRB2 GGNBP1 RNF10 SMAD1 SMAD4 TGFBR1
Entrez ID		440275
HPRD ID		18447
Ensembl ID		ENSG00000128829
Uniprot IDs		Q9P2K8
PDB IDs		6N3L 6N3N 6N3O 7E2K 7E2M 7QQ6 7QWK 8T7T
Enriched GO Terms of Interacting Partners?		Transforming Growth Factor Beta Receptor Signaling Pathway I-SMAD Binding Angiotensin Receptor Binding Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Adaptation Of Signaling Pathway Desensitization Of G Protein-coupled Receptor Signaling Pathway Ubiquitin Protein Ligase Binding Regulation Of Cardiac Muscle Hypertrophy SMAD Protein Complex Heteromeric SMAD Protein Complex Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Extracellular Matrix Assembly Endothelial Cell Activation G Protein-coupled Receptor Internalization Cardiac Conduction System Development Positive Regulation Of Cellular Component Organization Regulation Of Muscle Cell Differentiation Regulation Of Cardiac Muscle Cell Differentiation Negative Regulation Of Multicellular Organismal Process Regulation Of Extracellular Matrix Assembly Regulation Of System Process Cell Fate Commitment SMAD Protein Signal Transduction Regulation Of Protein Ubiquitination Positive Regulation Of Extracellular Matrix Organization Positive Regulation Of Receptor Internalization Cardiac Epithelial To Mesenchymal Transition Positive Regulation Of Macromolecule Biosynthetic Process Enzyme-linked Receptor Protein Signaling Pathway Activin Receptor Signaling Pathway Negative Regulation Of Cell Differentiation Positive Regulation Of Biosynthetic Process Positive Regulation Of Cardiac Muscle Hypertrophy Regulation Of Post-translational Protein Modification Regulation Of Muscle System Process Negative Regulation Of Cell Population Proliferation Negative Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Cell Differentiation Ventricular Septum Morphogenesis Neuron Fate Commitment Positive Regulation Of SMAD Protein Signal Transduction Regulation Of Multicellular Organismal Process Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Cellular Response To Growth Factor Stimulus Ventricular Cardiac Muscle Tissue Morphogenesis Postsynaptic Signal Transduction Transcription By RNA Polymerase II
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