ASL

Description		argininosuccinate lyase
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Extracellular Exosome
	Molecular Function	Catalytic Activity Argininosuccinate Lyase Activity Protein Binding Lyase Activity Identical Protein Binding
	Biological Process	Urea Cycle Amino Acid Metabolic Process Arginine Metabolic Process L-arginine Biosynthetic Process Locomotory Behavior Amino Acid Biosynthetic Process Post-embryonic Development Ammonia Assimilation Cycle L-arginine Biosynthetic Process Via Ornithine Positive Regulation Of Nitric Oxide Biosynthetic Process L-amino Acid Metabolic Process
Pathways		Urea cycle
Drugs		Arginine Argininosuccinate 2-(N-morpholino)ethanesulfonic acid
Diseases		Argininosuccinic aciduria (ARGINSA); Argininosuccinate lyase deficiency
GWAS
Novel Interacting Genes		10 novel interacting genes: CLK1 CSNK2A2 FBP1 HMOX1 MCMBP NTAQ1 OVGP1 QARS1 SRPK2 TRIM3
Interacting Genes		10 interacting genes: CLK1 CSNK2A2 FBP1 HMOX1 MCMBP NTAQ1 OVGP1 QARS1 SRPK2 TRIM3
Entrez ID		435
HPRD ID		01948
Ensembl ID		ENSG00000126522
Uniprot IDs		A0A024RDL8 A0A0S2Z316 P04424
PDB IDs		1AOS 1K62
Enriched GO Terms of Interacting Partners?		Protein Serine Kinase Activity Negative Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Catabolic Process Phosphoric Ester Hydrolase Activity Cellular Response To Raffinose Fructose 1,6-bisphosphate 1-phosphatase Activity Heme Oxidation Smooth Muscle Hyperplasia Heme Oxygenase (decyclizing) Activity Wound Healing Involved In Inflammatory Response Perivitelline Space Glutamine-tRNA Ligase Activity Glutaminyl-tRNA Aminoacylation Protein-N-terminal Asparagine Amidohydrolase Activity Protein-N-terminal Glutamine Amidohydrolase Activity Regulation Of Apoptotic Signaling Pathway Protein Serine/threonine Kinase Activity Protein Kinase CK2 Complex Cellular Hypotonic Salinity Response Cytosol Cellular Response To Cisplatin Negative Regulation Of Binding Of Sperm To Zona Pellucida Egg Coat Nuclear Speck Organization
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