MMP15

Description		matrix metallopeptidase 15
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space Plasma Membrane Membrane Extracellular Matrix
	Molecular Function	Metalloendopeptidase Activity Protein Binding Enzyme Activator Activity Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Hydrolase Activity Metal Ion Binding Metalloaminopeptidase Activity
	Biological Process	Proteolysis Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Catabolic Process Response To Estradiol Endodermal Cell Differentiation Protein Modification Process
Pathways		Collagen degradation Degradation of the extracellular matrix Degradation of the extracellular matrix Activation of Matrix Metalloproteinases
Drugs		Marimastat
Diseases
GWAS		Alanine aminotransferase levels ( 33547301 34315874) Aspartate aminotransferase levels ( 34315874) Chronic obstructive pulmonary disease ( 30804561) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Lung function (FEV1/FVC) ( 30804560) Peak expiratory flow ( 30804560) Pulmonary function ( 21946350) Pulmonary function (smoking interaction) ( 23284291)
Novel Interacting Genes		1 novel interacting genes: LRP1
Interacting Genes		1 interacting genes: LRP1
Entrez ID		4324
HPRD ID		03775
Ensembl ID		ENSG00000102996
Uniprot IDs		P51511
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Transcytosis Alpha-2 Macroglobulin Receptor Activity Apolipoprotein Receptor Activity Positive Regulation Of Reverse Cholesterol Transport Regulation Of Transcytosis Lipoprotein Particle Receptor Binding Astrocyte Activation Involved In Immune Response Negative Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Positive Regulation Of Lysosomal Protein Catabolic Process Positive Regulation Of Protein Catabolic Process In The Vacuole Positive Regulation Of Amyloid-beta Clearance Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Amyloid-beta Clearance By Cellular Catabolic Process Amyloid-beta Clearance By Transcytosis Clathrin Heavy Chain Binding Regulation Of Lysosomal Protein Catabolic Process Lipoprotein Transport Plasma Membrane Protein Complex Astrocyte Activation Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Heparan Sulfate Proteoglycan Binding Low-density Lipoprotein Particle Receptor Activity Apolipoprotein Binding Transcytosis Regulation Of Amyloid-beta Clearance Cargo Receptor Activity Aorta Morphogenesis Regulation Of Extracellular Matrix Disassembly Amyloid-beta Clearance Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Amyloid-beta Metabolic Process Scavenger Receptor Activity Apoptotic Cell Clearance Positive Regulation Of Cholesterol Efflux Negative Regulation Of SMAD Protein Signal Transduction Negative Regulation Of Smooth Muscle Cell Migration Positive Regulation Of Cholesterol Transport Regulation Of Cholesterol Efflux Cellular Response To Amyloid-beta Endocytic Vesicle Membrane Receptor Internalization Regulation Of SMAD Protein Signal Transduction Regulation Of Extracellular Matrix Organization Regulation Of Smooth Muscle Cell Migration Artery Morphogenesis Clathrin-coated Pit Retinoid Metabolic Process Regulation Of Cholesterol Transport Response To Amyloid-beta Positive Regulation Of Protein Localization To Plasma Membrane
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