MMP7

Description		matrix metallopeptidase 7
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Matrix Extracellular Exosome
	Molecular Function	Endopeptidase Activity Metalloendopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Hydrolase Activity Metal Ion Binding
	Biological Process	Antibacterial Peptide Secretion Antibacterial Peptide Biosynthetic Process Proteolysis Membrane Protein Ectodomain Proteolysis Response To Xenobiotic Stimulus Extracellular Matrix Disassembly Extracellular Matrix Organization Positive Regulation Of Cell Migration Collagen Catabolic Process Membrane Protein Intracellular Domain Proteolysis Regulation Of Cell Population Proliferation Defense Response To Bacterium Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium
Pathways		Collagen degradation Degradation of the extracellular matrix Degradation of the extracellular matrix Activation of Matrix Metalloproteinases Assembly of collagen fibrils and other multimeric structures Extra-nuclear estrogen signaling
Drugs		Marimastat (1R)-N,6-DIHYDROXY-7-METHOXY-2-[(4-METHOXYPHENYL)SULFONYL]-1,2,3,4-TETRAHYDROISOQUINOLINE-1-CARBOXAMIDE N4-HYDROXY-2-ISOBUTYL-N1-(9-OXO-1,8-DIAZA-TRICYCLO[10.6.1.013,18]NONADECA-12(19),13,15,17-TETRAEN-10-YL)-SUCCINAMIDE 5-METHYL-3-(9-OXO-1,8-DIAZA-TRICYCLO[10.6.1.013,18]NONADECA-12(19),13,15,17-TETRAEN-10-YLCARBAMOYL)-HEXANOIC ACID
Diseases
GWAS		Blood protein levels ( 30072576) Night sleep phenotypes ( 27126917) Prostate cancer ( 23535732) Prostate-specific antigen levels ( 28139693)
Novel Interacting Genes		16 novel interacting genes: BCAN CD151 CD44 DCN FASLG HAPLN1 HBEGF MBP MMP1 MMP9 NGF PLG SERPINA1 SPP1 TFPI TNFSF11
Interacting Genes		16 interacting genes: BCAN CD151 CD44 DCN FASLG HAPLN1 HBEGF MBP MMP1 MMP9 NGF PLG SERPINA1 SPP1 TFPI TNFSF11
Entrez ID		4316
HPRD ID		01525
Ensembl ID		ENSG00000137673
Uniprot IDs		P09237
PDB IDs		1MMP 1MMQ 1MMR 2DDY 2MZE 2MZH 2MZI 2Y6C 2Y6D 5UE2 5UE5 7WXX 8JUD 8JUF 8JUG 8K4Z
Enriched GO Terms of Interacting Partners?		Extracellular Region Extracellular Space Extracellular Matrix Cell Surface Hyaluronic Acid Binding Wound Healing, Spreading Of Cells Extracellular Matrix Disassembly Regulation Of Response To Wounding Cellular Response To UV-A Perineuronal Net Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Multicellular Organismal Process Positive Regulation Of Lipid Transport Extracellular Matrix Structural Constituent Conferring Compression Resistance Positive Regulation Of Keratinocyte Migration Response To UV-A Positive Regulation Of Bone Resorption Lysosomal Lumen Positive Regulation Of Cell Communication Positive Regulation Of Signaling Endopeptidase Activity Regulation Of Cellular Component Organization Cell Migration Golgi Lumen Transmembrane Receptor Protein Tyrosine Kinase Activator Activity Coagulation Blood Coagulation Protease Binding Peptidase Inhibitor Activity Hemostasis Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Collateral Sprouting System Development Developmental Process Cell Motility Regulation Of Lipid Transport Regulation Of Wound Healing Positive Regulation Of Signal Transduction Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Cellular Component Organization Positive Regulation Of Intracellular Signal Transduction Tumor Necrosis Factor Receptor Binding Central Nervous System Development Extracellular Matrix Binding Serine-type Endopeptidase Activity Regulation Of Apoptotic Signaling Pathway Signaling Receptor Binding Positive Regulation Of ERBB Signaling Pathway Regulation Of Bone Resorption Collagen Catabolic Process
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