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MITF
Description
melanocyte inducing transcription factor
Image
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Cytoplasm
Lysosome
Lysosomal Membrane
Cytosol
Membrane
Protein-containing Complex
Molecular Function
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
Chromatin Binding
DNA-binding Transcription Factor Activity
Protein Binding
Protein Dimerization Activity
E-box Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Regulation Of DNA-templated Transcription
Regulation Of Transcription By RNA Polymerase II
Regulation Of Gene Expression
Positive Regulation Of Gene Expression
Wnt Signaling Pathway
Cell Differentiation
Osteoclast Differentiation
Melanocyte Differentiation
Negative Regulation Of Cell Migration
Regulation Of Cell Population Proliferation
Camera-type Eye Development
Negative Regulation Of Apoptotic Process
Pigmentation
Cell Fate Commitment
Regulation Of Osteoclast Differentiation
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Bone Remodeling
Protein-containing Complex Assembly
Melanocyte Apoptotic Process
Positive Regulation Of DNA-templated Transcription Initiation
Regulation Of RNA Biosynthetic Process
Pathways
SUMOylation of transcription factors
Transcriptional and post-translational regulation of MITF-M expression and activity
Drugs
Diseases
Malignant melanoma
Ocular albinism; Ocular albinism, type I (OA1); Waardenburg syndrome, type II (WS2-OA)
Waardenburg syndrome (WS)
GWAS
Apolipoprotein B levels (
32203549
)
Blond vs. brown/black hair color (
30531825
)
Brain morphology (min-P) (
32665545
)
Brain morphology (MOSTest) (
32665545
)
Carotid intima media thickness x smoking interaction (
32117412
)
Chronotype (
30696823
)
Circulating fibroblast growth factor 23 levels (
30217807
)
Coronary artery disease (
33020668
)
Cortical surface area (MOSTest) (
32665545
)
Cutaneous malignant melanoma (
32341527
)
Hematocrit (
32888494
27863252
)
Hemoglobin (
32888494
)
Hemoglobin concentration (
27863252
)
Hemoglobin levels (
32327693
)
Hypertrophic cardiomyopathy (sarcomere negative) (
33495597
)
LDL cholesterol levels (
32203549
)
Low density lipoprotein cholesterol levels (
32154731
)
Myocardial infarction (
33532862
)
Neutrophil count (
32888494
)
Nevus count or cutaneous melanoma (
32341527
)
Platelet count (
32888494
)
Plateletcrit (
32888494
)
Pulse pressure (
27841878
)
QRS complex (12-leadsum) (
27659466
)
Red blood cell count (
32888494
27863252
)
Renal underexcretion gout (
32238385
)
Severe influenza A (H1N1) infection (
26379185
)
Subcortical volume (min-P) (
32665545
)
Subcortical volume (MOSTest) (
32665545
)
Systolic blood pressure (
27841878
)
Triglyceride levels (
32203549
)
Waist-hip index (
34021172
)
Novel Interacting Genes
35 novel interacting genes:
ADRB2
APP
BTRC
CLK4
CTNNB1
EBP
EP300
FBXO7
FBXW11
FOS
GSK3B
HINT1
HK3
LEF1
MAPK1
MAPK14
MARK3
OTX2
PATZ1
PAX3
PAX6
PDGFRB
PIAS1
PIAS2
PIAS3
PSMD14
RERE
RPS6KA1
SPI1
STUB1
SUMO1
TFE3
TFEB
TFEC
UBE2I
Interacting Genes
35 interacting genes:
ADRB2
APP
BTRC
CLK4
CTNNB1
EBP
EP300
FBXO7
FBXW11
FOS
GSK3B
HINT1
HK3
LEF1
MAPK1
MAPK14
MARK3
OTX2
PATZ1
PAX3
PAX6
PDGFRB
PIAS1
PIAS2
PIAS3
PSMD14
RERE
RPS6KA1
SPI1
STUB1
SUMO1
TFE3
TFEB
TFEC
UBE2I
Entrez ID
4286
HPRD ID
01138
Ensembl ID
ENSG00000187098
Uniprot IDs
A0A087WXU1
A0A8I5KSZ4
B4DNC7
O75030
PDB IDs
4C7N
7D8R
7D8S
7D8T
7EOD
8E1D
Enriched GO Terms of Interacting Partners
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Regulation Of DNA-templated Transcription
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of RNA Biosynthetic Process
Regulation Of Primary Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Regulation Of Transcription By RNA Polymerase II
Regulation Of RNA Metabolic Process
Positive Regulation Of Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Nucleus
Positive Regulation Of RNA Metabolic Process
Regulation Of Metabolic Process
Regulation Of Macromolecule Metabolic Process
Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Biosynthetic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Regulation Of Gene Expression
Protein Modification Process
Positive Regulation Of Transcription By RNA Polymerase II
Nucleoplasm
Negative Regulation Of RNA Metabolic Process
Enzyme Binding
Ubiquitin Protein Ligase Binding
Regulation Of Intracellular Signal Transduction
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Transcription Coregulator Binding
Negative Regulation Of Transcription By RNA Polymerase II
Regulation Of Signal Transduction
Post-translational Protein Modification
Protein Sumoylation
Cell Surface Receptor Signaling Pathway
SUMO Transferase Activity
Positive Regulation Of Cell Differentiation
Chromatin
Protein Metabolic Process
Regulation Of Cell Differentiation
Positive Regulation Of Developmental Process
Regulation Of Hemopoiesis
Positive Regulation Of Proteolysis
Negative Regulation Of Intracellular Signal Transduction
Regulation Of Myeloid Cell Differentiation
Regulation Of Cell Communication
Regulation Of Signaling
Presynaptic Cytosol
Postsynaptic Cytosol
Chromatin Binding
Tagcloud
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