MGP

Description		matrix Gla protein
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Matrix Extracellular Exosome
	Molecular Function	Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding Structural Constituent Of Bone
	Biological Process	Cartilage Condensation Ossification Cell Differentiation Regulation Of Bone Mineralization System Development Cartilage Development
Pathways
Drugs		Calcium
Diseases		Keutel syndrome
GWAS		Finger osteoarthritis severity (hand Klsum) ( 33055079) Hand osteoarthritis severity (hand Klsum) ( 33055079) Heel bone mineral density ( 30598549) Osteoarthritis of the hand ( 28855172)
Novel Interacting Genes		2 novel interacting genes: BMP2 CFTR
Interacting Genes		2 interacting genes: BMP2 CFTR
Entrez ID		4256
HPRD ID		01112
Ensembl ID		ENSG00000111341
Uniprot IDs		P08493
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Biomineral Tissue Development Odontogenesis Of Dentin-containing Tooth Odontogenesis Embryonic Heart Tube Anterior/posterior Pattern Specification Positive Regulation Of Secretion Negative Regulation Of Aldosterone Biosynthetic Process Cardiac Jelly Development Cardiac Atrium Formation Negative Regulation Of Cortisol Biosynthetic Process Positive Regulation Of Phosphatase Activity Positive Regulation Of Bone Mineralization Involved In Bone Maturation Endodermal-mesodermal Cell Signaling Positive Regulation Of Secretion By Cell Atrioventricular Canal Morphogenesis Negative Regulation Of Calcium-independent Cell-cell Adhesion Mesenchymal Cell Proliferation Involved In Ureteric Bud Development Positive Regulation Of Extracellular Matrix Constituent Secretion Enzyme Activator Complex Corticotropin Hormone Secreting Cell Differentiation BMP Receptor Complex Positive Regulation Of Anion Channel Activity Positive Regulation Of Enamel Mineralization Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Positive Regulation Of Monoatomic Anion Transport Regulation Of Extracellular Matrix Constituent Secretion Regulation Of Cortisol Biosynthetic Process Regulation Of Aldosterone Biosynthetic Process Positive Regulation Of Dephosphorylation Pericardium Development Thyroid-stimulating Hormone-secreting Cell Differentiation Heart Induction Ameloblast Differentiation Positive Regulation Of Odontogenesis Telencephalon Regionalization Negative Regulation Of Steroid Hormone Biosynthetic Process Semi-lunar Valve Development Negative Regulation Of Glucocorticoid Biosynthetic Process Positive Regulation Of Odontoblast Differentiation Aortic Valve Development Animal Organ Morphogenesis Positive Regulation Of Neuroepithelial Cell Differentiation Phosphatase Activator Activity Bicarbonate Transmembrane Transporter Activity Intracellular PH Elevation Positive Regulation Of Tooth Mineralization Chloride Channel Inhibitor Activity Transepithelial Water Transport Chloride Channel Regulator Activity
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