MECP2

Description		methyl-CpG binding protein 2
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GO Annotations	Cellular Component	Chromatin Heterochromatin Extracellular Space Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Synapse Postsynapse
	Molecular Function	Nucleic Acid Binding DNA Binding Chromatin Binding Transcription Corepressor Activity RNA Binding MRNA Binding Protein Binding Methyl-CpG Binding Double-stranded Methylated DNA Binding SiRNA Binding Molecular Adaptor Activity Histone Reader Activity Molecular Condensate Scaffold Activity Promoter-specific Chromatin Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Behavioral Fear Response Response To Hypoxia Startle Response Nervous System Process Involved In Regulation Of Systemic Arterial Blood Pressure Regulation Of Respiratory Gaseous Exchange By Nervous System Process Inositol Metabolic Process Regulation Of Transcription By RNA Polymerase II Glutamine Metabolic Process Biogenic Amine Metabolic Process Notch Signaling Pathway Chemical Synaptic Transmission Synapse Assembly Brain Development Respiratory Gaseous Exchange By Respiratory System Learning Memory Long-term Memory Intracellular Protein Localization Glucocorticoid Metabolic Process Cell Population Proliferation Associative Learning Adult Locomotory Behavior Visual Learning Post-embryonic Development Gene Expression Regulation Of Gene Expression Negative Regulation Of Gene Expression Glial Cell Proliferation Dendrite Development Negative Regulation Of Angiogenesis Proprioception Sensory Perception Of Pain Cerebellum Development Ventricular System Development Neuron Differentiation Neuron Projection Development Heterochromatin Formation Cardiolipin Metabolic Process Multicellular Organismal Response To Stress Social Behavior Epigenetic Regulation Of Gene Expression Neuron Maturation Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Phosphatidylcholine Metabolic Process Regulation Of Synaptic Plasticity Cell Development Catecholamine Secretion Neuromuscular Process Controlling Posture Neuromuscular Process Negative Regulation Of Developmental Process Negative Regulation Of Smooth Muscle Cell Differentiation Response To Other Organism Excitatory Postsynaptic Potential Positive Regulation Of Glial Cell Proliferation Long-term Synaptic Potentiation Genomic Imprinting Positive Regulation Of Microtubule Nucleation Trans-synaptic Signaling By BDNF Regulation Of Multicellular Organismal Development
Pathways
Drugs
Diseases		Non-syndromic X-linked mental retardation Prader-Willi and Angelman syndromes, including: Angelman syndrome (AS); Prader-Willi syndrome (PWS) Rett syndrome
GWAS		Non-albumin protein levels ( 29403010) Red blood cell traits ( 23446634) Schizophrenia ( 24043878) Systemic lupus erythematosus ( 19838195 26502338 26663301)
Novel Interacting Genes		18 novel interacting genes: DNMT1 DNMT3L GTF2B H3C15 HIPK2 HMGB1 NCOR1 PRKACA PRPF40A PRPF40B SIN3A SKI SMARCA2 SMARCB1 SOX18 SPI1 TBL1X TBL1XR1
Interacting Genes		18 interacting genes: DNMT1 DNMT3L GTF2B H3C15 HIPK2 HMGB1 NCOR1 PRKACA PRPF40A PRPF40B SIN3A SKI SMARCA2 SMARCB1 SOX18 SPI1 TBL1X TBL1XR1
Entrez ID		4204
HPRD ID		02050
Ensembl ID		ENSG00000169057
Uniprot IDs		A0A140VKC4 D3YJ43 P51608 Q59FJ6
PDB IDs		1QK9 3C2I 5BT2 6C1Y 6OGJ 6OGK 6YWW 8AJR 8ALQ
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Organization Negative Regulation Of DNA-templated Transcription Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Transcription Repressor Complex Epigenetic Regulation Of Gene Expression Chromatin Remodeling Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Transcription Cis-regulatory Region Binding Negative Regulation Of Metabolic Process Nucleus Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Transcription Corepressor Activity Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Histone Deacetylase Complex Nucleoplasm Regulation Of RNA Metabolic Process Heterochromatin Formation Negative Regulation Of Gene Expression, Epigenetic DNA Binding Regulation Of Gene Expression RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of Biosynthetic Process Positive Regulation Of DNA Binding Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Germ Cell Nucleus Regulation Of Nucleotide-excision Repair Regulation Of Myeloid Progenitor Cell Differentiation Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Regulation Of DNA Binding Positive Regulation Of Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Stem Cell Population Maintenance Positive Regulation Of Metabolic Process Cellular Developmental Process Regulation Of Metabolic Process DNA-binding Transcription Factor Binding Positive Regulation Of RNA Metabolic Process Regulation Of Carbohydrate Catabolic Process Positive Regulation Of Leukocyte Differentiation
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