ME2

Description		malic enzyme 2
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix
	Molecular Function	Catalytic Activity Malic Enzyme Activity Malate Dehydrogenase (decarboxylating) (NAD+) Activity Malate Dehydrogenase (decarboxylating) (NADP+) Activity Oxaloacetate Decarboxylase Activity Electron Transfer Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Metal Ion Binding NAD Binding
	Biological Process	Pyruvate Metabolic Process Malate Metabolic Process Regulation Of NADP Metabolic Process
Pathways		Pyruvate metabolism Mitochondrial protein degradation
Drugs		NADH Fumaric acid D-Malic acid Mesoxalic acid Tartronate
Diseases
GWAS		Entorhinal cortical thickness ( 21116278) Eosinophil percentage of white cells ( 32888494) Metabolite levels ( 23823483) Pneumococcal meningitis ( 31092817)
Novel Interacting Genes		3 novel interacting genes: DYNLL1 OGT TCAIM
Interacting Genes		3 interacting genes: DYNLL1 OGT TCAIM
Entrez ID		4200
HPRD ID		01103
Ensembl ID		ENSG00000082212
Uniprot IDs		P23368
PDB IDs		1DO8 1EFK 1EFL 1GZ3 1GZ4 1PJ2 1PJ3 1PJ4 1PJL 1QR6 7BSJ 7BSK 7BSL 7XDE 7XDF 7XDG 9AYI
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Protein N-acetylglucosaminyltransferase Complex Non-canonical Inflammasome Complex Assembly Negative Regulation Of Non-canonical Inflammasome Complex Assembly Mitochondrion Positive Regulation Of Transcription By Glucose Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Protein O-acetylglucosaminyltransferase Activity Deoxyribonuclease Inhibitor Activity Negative Regulation Of DNA Strand Resection Involved In Replication Fork Processing Regulation Of DNA Strand Resection Involved In Replication Fork Processing Nitric-oxide Synthase Inhibitor Activity Carbon Catabolite Regulation Of Transcription Nitric-oxide Synthase Regulator Activity Regulation Of Transcription By Glucose NSL Complex Negative Regulation Of DNA-templated DNA Replication Intraciliary Retrograde Transport Regulation Of Cellular Localization Negative Regulation Of Nitric Oxide Biosynthetic Process DNA Strand Resection Involved In Replication Fork Processing Acetylglucosaminyltransferase Activity Regulation Of Phosphorus Metabolic Process Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane
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