MAN2B1

Description		mannosidase alpha class 2B member 1
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleoplasm Lysosome Azurophil Granule Lumen Lysosomal Lumen Extracellular Exosome
	Molecular Function	Catalytic Activity Alpha-mannosidase Activity Hydrolase Activity Hydrolase Activity, Acting On Glycosyl Bonds Carbohydrate Binding Metal Ion Binding
	Biological Process	Carbohydrate Metabolic Process Mannose Metabolic Process Protein Deglycosylation Learning Or Memory Oligosaccharide Catabolic Process Protein Modification Process
Pathways		Neutrophil degranulation Lysosomal oligosaccharide catabolism
Drugs
Diseases		alpha-Mannosidosis
GWAS		Pulmonary emphysema ( 24383474)
Novel Interacting Genes		2 novel interacting genes: NKX3-1 SMAD9
Interacting Genes		2 interacting genes: NKX3-1 SMAD9
Entrez ID		4125
HPRD ID		02007
Ensembl ID		ENSG00000104774
Uniprot IDs		A8K6A7 O00754
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Androgen Secretion MADS Box Domain Binding Dorsal Aorta Development DNA-binding Transcription Factor Activity Heteromeric SMAD Protein Complex SMAD Protein Complex Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Epithelial Cell Proliferation Involved In Salivary Gland Morphogenesis Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Salivary Gland Development Branching Involved In Prostate Gland Morphogenesis Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Epithelial Cell Proliferation Involved In Prostate Gland Development I-SMAD Binding Prostate Gland Development Urogenital System Development Pharyngeal System Development SMAD Protein Signal Transduction Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Prostate Gland Epithelium Morphogenesis Androgen Receptor Signaling Pathway RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Cellular Response To BMP Stimulus DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Chromatin Aorta Development Metanephros Development Nuclear Estrogen Receptor Binding Transcription Regulator Inhibitor Activity Response To Testosterone Positive Regulation Of Transcription By RNA Polymerase II Somitogenesis Artery Development Site Of DNA Damage Cellular Response To Interleukin-1 Segmentation Nuclear Receptor Activity Anatomical Structure Morphogenesis Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Cellular Response To Xenobiotic Stimulus Intracellular Iron Ion Homeostasis Negative Regulation Of Reproductive Process BMP Signaling Pathway Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Response To Interleukin-1 Cellular Response To Steroid Hormone Stimulus Positive Regulation Of Lipid Transport Steroid Hormone Receptor Signaling Pathway
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